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1. Acute renal failure was produced in rats by the intramuscular injection of glycerol (6.1 mol/l 10 ml/kg). Either 2 or 4--6 h later the right kidney was isolated and perfused for 1 h with an electrolyte solution containing a gelatin preparation (Haemaccel, 35 g/l) at pressures between 90 and 100 mm Hg in a single-pass system. 2. In kidneys taken from rats with acute renal failure renal vascular resistance was markedly increased immediately after the start of the perfusion as compared with control kidneys taken from untreated rats. During the following 30 min of perfusion the resistance progressively decreased and, at 1 h of perfusion, was similar to that in control kidneys or only moderately elevated. 3. Despite the reduction of renal vascular resistance glomerular filtration rate was still markedly increased immediately after the start of the perfusion as compared with control kidneys taken from untreated rats. During the following 30 min of perfusion the resistance progressively decreased and, at 1 h of perfusion, was similar to that in control kidneys or only moderately elevated. 3. Despite the reduction of renal vascular resistance glomerular filtration rate was still markedly impaired after 1 h of perfusion and fractional reabsorption of sodium and water as well as the secretion of p-aminohippurate were diminished. Renal venous renin concentration and renin release were lower in kidneys taken from rats with acute renal failure than in the control experiments. 4. These results suggest that the increase in renal vascular resistance and the stimulation of renin release after injection of glycerol in vivo are the consequence of extra- rather than intra-renal mechanisms.
K G Hofbauer, and
K Bauereiss, and
A Konrads, and
F Gross
September 1977,
The American journal of physiology,
K G Hofbauer, and
K Bauereiss, and
A Konrads, and
F Gross
August 1981,
Experimental and molecular pathology,
K G Hofbauer, and
K Bauereiss, and
A Konrads, and
F Gross
January 1992,
Nephron,
K G Hofbauer, and
K Bauereiss, and
A Konrads, and
F Gross
June 2010,
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
K G Hofbauer, and
K Bauereiss, and
A Konrads, and
F Gross
November 1987,
The American journal of physiology,
K G Hofbauer, and
K Bauereiss, and
A Konrads, and
F Gross
December 1989,
Circulation research,
K G Hofbauer, and
K Bauereiss, and
A Konrads, and
F Gross
January 1987,
The American journal of cardiology,
K G Hofbauer, and
K Bauereiss, and
A Konrads, and
F Gross
February 1989,
Toxicology letters,
K G Hofbauer, and
K Bauereiss, and
A Konrads, and
F Gross
May 1980,
Clinical science (London, England : 1979),
K G Hofbauer, and
K Bauereiss, and
A Konrads, and
F Gross
January 1980,
Nephron,
