Biomaterial Database

Cardiac output by dye dilution using a left carotid loop in conscious rats. 1980

K Matsunaga, and N Imamura, and M Ueda

By a modified dye dilution method using a simple dichromatic densitometer, cardiac output (CO) in conscious rats was determined. Under anesthesia, a carotid loop was made in the left carotid artery with a polyethylene tube (PE50) and exteriorized. A sensor of the densitometer was set at the center of the carotid loop. Indocyanine green dye solution was injected into the right atrium via the jugular vein. CO was calculated from the dye dilution curve obtained. In the conscious state (6 hours after ether anesthesia),CO in normotensive, spontaneously and DOC/saline hypertensive rats was determined without affecting blood pressure and heart rate. However, CO in the pentobarbital or urethane anesthetized rats was decreased with other hemodynamic changes. The validity of this method was confirmed with a hydraulic model system and in anesthetized open-chest cats using an electromagnetic flowmetry. From these studies, it was concluded that the modifed dye dilution method for measuring CO in conscious rats was reliable and useful for hemodynamic studies in hypertensive rats.

UI	MeSH Term	Description	Entries
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002302	Cardiac Output	The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).	Cardiac Outputs,Output, Cardiac,Outputs, Cardiac
D003720	Densitometry	The measurement of the density of a material by measuring the amount of light or radiation passing through (or absorbed by) the material.	Densitometries
D004395	Dye Dilution Technique	Method for assessing flow through a system by injection of a known quantity of dye into the system and monitoring its concentration over time at a specific point in the system. (From Dorland, 28th ed)	Dye Dilution Technic,Dilution Technic, Dye,Dilution Technics, Dye,Dilution Technique, Dye,Dilution Techniques, Dye,Dye Dilution Technics,Dye Dilution Techniques,Technic, Dye Dilution,Technics, Dye Dilution,Technique, Dye Dilution,Techniques, Dye Dilution
D006339	Heart Rate	The number of times the HEART VENTRICLES contract per unit of time, usually per minute.	Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D055590	Electromagnetic Phenomena	Characteristics of ELECTRICITY and magnetism such as charged particles and the properties and behavior of charged particles, and other phenomena related to or associated with electromagnetism.	Electrical Concepts,Electromagnetic Concepts,Electrical Phenomena,Electrical Phenomenon,Electromagnetic Phenomenon,Electromagnetics,Concept, Electrical,Concept, Electromagnetic,Concepts, Electrical,Concepts, Electromagnetic,Electrical Concept,Electromagnetic Concept,Electromagnetic Phenomenas,Phenomena, Electrical,Phenomena, Electromagnetic,Phenomenon, Electrical,Phenomenon, Electromagnetic