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Cultured human lymphocytes of the IM-9 line have specific binding sites for 125I-insulin that have been characterized in detail. When the hormone--cell interaction was studied by quantitative electron microscopic (EM) autoradiography, it was shown that initial binding was to the plasma membrane and that at 37 degrees C a small fraction of the ligand was internalized by the cell. The internalized ligand was found preferentially localized in lysosomes in the Golgi region of the cell. It is well known that di- or multivalent ligands redistribute in the plane of the membrane before internalization. We now report that following initial binding the univalent ligand insulin also undergoes a polar redistribution ('capping') before internalization.
P Barazzone, and
J L Carpentier, and
P Gorden, and
E Van Obberghen, and
L Orci
October 1981,
The Journal of cell biology,
P Barazzone, and
J L Carpentier, and
P Gorden, and
E Van Obberghen, and
L Orci
July 1981,
Experimental cell research,
P Barazzone, and
J L Carpentier, and
P Gorden, and
E Van Obberghen, and
L Orci
July 1983,
Biochemical and biophysical research communications,
P Barazzone, and
J L Carpentier, and
P Gorden, and
E Van Obberghen, and
L Orci
August 1980,
Nature,
P Barazzone, and
J L Carpentier, and
P Gorden, and
E Van Obberghen, and
L Orci
February 1979,
Immunology,
P Barazzone, and
J L Carpentier, and
P Gorden, and
E Van Obberghen, and
L Orci
February 1972,
Nature: New biology,
P Barazzone, and
J L Carpentier, and
P Gorden, and
E Van Obberghen, and
L Orci
January 1981,
Diabetes care,
P Barazzone, and
J L Carpentier, and
P Gorden, and
E Van Obberghen, and
L Orci
May 1985,
Diabetes research (Edinburgh, Scotland),
P Barazzone, and
J L Carpentier, and
P Gorden, and
E Van Obberghen, and
L Orci
August 1983,
The Kobe journal of medical sciences,
P Barazzone, and
J L Carpentier, and
P Gorden, and
E Van Obberghen, and
L Orci
December 1981,
Molecular and cellular biology,
