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Relation of antibody-coated urine bacteria to the site(s) of infection in experimental dogs. 1980

G V Ling, and N Ackerman, and A L Ruby

Antibody-coated bacteria tests, using fluorescein-conjugated rabbit anti-canine immunoglobulin (Ig)G and anti-IgA, were conducted on 77 specimens of bladder urine obtained by antepubic cystocentesis from 25 dogs with urinary tract infections. Urine specimens from 3 dogs infected with Staphylococcus aureus were tested a total of 27 times, specimens from 10 dogs infected with Escherichia coli were tested 25 times, urine from 6 dogs infected with Proteus mirabilis was sampled and tested 18 times, urine from 3 dogs with Klebsiella pneumoniae was sampled and tested 4 times, and specimens from 3 dogs infected with P rettgeri, Enterobacter cloacae, or Streptococcus faecalis were tested once each. Specimens of urine from the renal pelves of each dogs were obtained by percutaneous nephropyelocentesis at the same time as the specimens of bladder urine. The results of bacterial cultures of these specimens were compared with the results of the corresponding antibody-coated bacteria tests. False-positive results (ie, evidence of antibody coating of bladder urine bacteria but no bacterial growth from corresponding renal pelvis urine specimens) were obtained in 13 of 22 (59%) tests of dogs infected with S aureus, 12 of 13 (92%) tests in dogs infected with P mirabiis, 5 of 18(28%) tests in dogs infected with E coli, and 1 of 4 (25%) tests in dogs infected with K pneumoniae. False-negative results (ie, bacterial growth from renal pelvis urine specimens but no evidence of antibody coating of bacteria in the corresponding specimen of bladder urine) occurred in 5 of 7 (71%) specimens infected with E coli, in 4 of 5 (80%) specimens infected with P mirabilis, and in 5 of 5 (100%) specimens infected with S aureus. It was concluded that the antibody-coated bacteria test does not provide accurate information to support the diagnosis of pyelonephritis in the dog.

UI MeSH Term Description Entries
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D008297 Male Males
D010388 Pelvis The space or compartment surrounded by the pelvic girdle (bony pelvis). It is subdivided into the greater pelvis and LESSER PELVIS. The pelvic girdle is formed by the PELVIC BONES and SACRUM. Pelvic Region,Region, Pelvic
D011704 Pyelonephritis Inflammation of the KIDNEY involving the renal parenchyma (the NEPHRONS); KIDNEY PELVIS; and KIDNEY CALICES. It is characterized by ABDOMINAL PAIN; FEVER; NAUSEA; VOMITING; and occasionally DIARRHEA. Necrotizing Pyelonephritis,Pyelonephritis, Acute Necrotizing,Pyelonephritides
D001743 Urinary Bladder A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION. Bladder,Bladder Detrusor Muscle,Detrusor Urinae,Bladder Detrusor Muscles,Bladder, Urinary,Detrusor Muscle, Bladder,Detrusor Muscles, Bladder
D004283 Dog Diseases Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used. Canine Diseases,Canine Disease,Disease, Canine,Disease, Dog,Diseases, Canine,Diseases, Dog,Dog Disease
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D005188 False Negative Reactions Negative test results in subjects who possess the attribute for which the test is conducted. The labeling of diseased persons as healthy when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed) False Negative Reaction,Reaction, False Negative,Reactions, False Negative
D005189 False Positive Reactions Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed) False Positive Reaction,Positive Reaction, False,Positive Reactions, False,Reaction, False Positive,Reactions, False Positive
D005260 Female Females

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