Ten patients suffering from genital organ infections, urinary tract infections and symptomless bacteriuria were treated with cefamandole (CMD). CMD was administered intravenously and drip infusion at a dosage of 4.0 g/day for 4 approximately 10 days. Clinical results obtained were as follows: Of 6 patients with genital organ infections, excellent responses were seen in 2 patients, good responses in 4 patients. Of 3 patients with urinary tract infections, excellent responses were seen in 2 patients, and good response in 1 patient. The overall efficacy rate was 100%. In the cases of urinary tract infections and symptomless bacteriuria, 3 strains of E. coli and 1 strain of Streptococcus faecalis disappeared. On the other hand, in genital organ infections, we had no bacterial findings. No significant reaction was observed in clinical laboratory findings of hemogram or in test on renal and hepatic functions, except slight transient leukopenia observed in 1 patient.