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The influence of sex steroids on the production of prostacyclin (PGI2) like material by the isolated rat uterus incubated in a buffer medium was explored by monitoring its ability to inhibit ADP-induced platelet aggregation. Chopped uterine strips from rats in natural estrus can generate an unstable substance that inhibits platelet aggregation and suggest to be prostacyclin. This capacity was significantly enhanced in preparations from spayed animals. The injection of 17-beta estradiol; progesterone or both diminished the production of the prostacyclin-like material by the uterus from ovariectomized rats. The already existing notion that ovarian steroids are able to regulate the synthesis of stable prostaglandins is discussed together with the present results suggesting in addition a depressive effect of sex hormones on the uterine PGI2 synthetase system.
M F Gimeno, and
E S Borda, and
M A Lazzari, and
A L Gimeno
June 1974,
Life sciences,
M F Gimeno, and
E S Borda, and
M A Lazzari, and
A L Gimeno
December 1978,
Japanese journal of pharmacology,
M F Gimeno, and
E S Borda, and
M A Lazzari, and
A L Gimeno
October 1983,
Japanese journal of pharmacology,
M F Gimeno, and
E S Borda, and
M A Lazzari, and
A L Gimeno
November 1992,
The American review of respiratory disease,
M F Gimeno, and
E S Borda, and
M A Lazzari, and
A L Gimeno
March 1953,
The American journal of physiology,
M F Gimeno, and
E S Borda, and
M A Lazzari, and
A L Gimeno
July 1980,
Neuropharmacology,
M F Gimeno, and
E S Borda, and
M A Lazzari, and
A L Gimeno
January 1982,
Prostaglandins,
M F Gimeno, and
E S Borda, and
M A Lazzari, and
A L Gimeno
June 1961,
Endocrinology,
M F Gimeno, and
E S Borda, and
M A Lazzari, and
A L Gimeno
March 1976,
British journal of pharmacology,
M F Gimeno, and
E S Borda, and
M A Lazzari, and
A L Gimeno
May 1960,
Acta endocrinologica,
