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Forty-year-old individuals with labile and with mild sustained essential hypertension, identified during a survey of a population born in 1936, were investigated. None had ever received antihypertensive treatment. In thirty-three individuals (26 M, 7F) with diastolic blood pressure (DBP) greater than or equal to 95 mmHg at the very first examination and in thirty-one (14 M, 17 F) randomly selected normotensive controls plasma noradrenaline concentration (PNAC) was measured at rest supine. In twenty-two patients (16 M, 6 F), with sustained diastolic hypertension (diastolic blood pressure greater than or equal to 95 mmHg on at least three different occasions) and in twenty-four (14 M, 10 F) normotensive controls PNAC and plasma renin concentration (PRC) were measured supine at rest and again 2 h after furosemide and ambulation. Basal and acutely stimulated values for PNAC and PRC were identical in hypertensive and normotensive individuals. A close correlation between PNAC and PRC after acute stimulation (r = 0.77, P < 0.001) as well as between the absolute changes from resting to acutely stimulated values (r = 0.72, P < 0.001) were found in the hypertensive individuals. It is concluded that sympathetic nerve activity, as defined from measurements of plasma noradrenaline concentration, is similar in young patients with mild hypertension and in normotensive controls. We propose that the discrepancies found in the literature might be related to a lack of comparability between hypertensive and normotensive individuals studied, as far as the source of study populations is concerned.
H Ibsen, and
N J Christensen, and
H Hollnagel, and
A Leth, and
A M Kappelgaard, and
J Giese
August 1981,
Clinical science (London, England : 1979),
H Ibsen, and
N J Christensen, and
H Hollnagel, and
A Leth, and
A M Kappelgaard, and
J Giese
May 1981,
Clinical science (London, England : 1979),
H Ibsen, and
N J Christensen, and
H Hollnagel, and
A Leth, and
A M Kappelgaard, and
J Giese
January 1983,
Acta physiologica Scandinavica,
H Ibsen, and
N J Christensen, and
H Hollnagel, and
A Leth, and
A M Kappelgaard, and
J Giese
January 1976,
Acta medica Scandinavica,
H Ibsen, and
N J Christensen, and
H Hollnagel, and
A Leth, and
A M Kappelgaard, and
J Giese
January 1977,
Bollettino della Societa italiana di cardiologia,
H Ibsen, and
N J Christensen, and
H Hollnagel, and
A Leth, and
A M Kappelgaard, and
J Giese
January 1975,
Clinical and experimental pharmacology & physiology,
H Ibsen, and
N J Christensen, and
H Hollnagel, and
A Leth, and
A M Kappelgaard, and
J Giese
January 1977,
Postgraduate medical journal,
H Ibsen, and
N J Christensen, and
H Hollnagel, and
A Leth, and
A M Kappelgaard, and
J Giese
April 1962,
Circulation research,
H Ibsen, and
N J Christensen, and
H Hollnagel, and
A Leth, and
A M Kappelgaard, and
J Giese
January 1980,
Nephron,
H Ibsen, and
N J Christensen, and
H Hollnagel, and
A Leth, and
A M Kappelgaard, and
J Giese
February 1984,
Journal of hypertension,
