-transparent.png){kind=logo}
Glucose, lactate, non-esterified fatty acid and insulin levels in plasma were measured in two groups of 12 patients undergoing gastrectomy under general anaesthesia. Propranolol in a dose of 0.3 mg/kg body weight was intraoperatively infused in one of the two groups. Surgery under general anaesthesia elicited a significant rise in blood glucose, lactate and NEFA concentrations. These metabolic responses were significantly inhibited by intraoperative infusion of propranolol without producing any undesirable side effect. Plasma insulin levels showed a slight decrease during the operation and no significant difference was noted between the two groups. The results suggest that beta-adrenergic activity is playing a major role in these metabolic responses, promoting the mobilization of substrates. Possible benefits of inhibiting beta-adrenergic activation in surgical stress are discussed.
H Tsuji, and
T Asoh, and
C Shirasaka, and
Y Takeuchi
December 1980,
British journal of anaesthesia,
H Tsuji, and
T Asoh, and
C Shirasaka, and
Y Takeuchi
October 1981,
Journal of applied physiology: respiratory, environmental and exercise physiology,
H Tsuji, and
T Asoh, and
C Shirasaka, and
Y Takeuchi
July 1988,
The American journal of physiology,
H Tsuji, and
T Asoh, and
C Shirasaka, and
Y Takeuchi
January 1984,
European journal of applied physiology and occupational physiology,
H Tsuji, and
T Asoh, and
C Shirasaka, and
Y Takeuchi
May 1967,
American heart journal,
H Tsuji, and
T Asoh, and
C Shirasaka, and
Y Takeuchi
June 1985,
Medicine and science in sports and exercise,
H Tsuji, and
T Asoh, and
C Shirasaka, and
Y Takeuchi
June 1992,
Journal of applied physiology (Bethesda, Md. : 1985),
H Tsuji, and
T Asoh, and
C Shirasaka, and
Y Takeuchi
July 1987,
Diabetes research (Edinburgh, Scotland),
H Tsuji, and
T Asoh, and
C Shirasaka, and
Y Takeuchi
March 1989,
Canadian journal of physiology and pharmacology,
H Tsuji, and
T Asoh, and
C Shirasaka, and
Y Takeuchi
May 1983,
Chest,
