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A series of hydroxyl radical (.OH) scavenging agents competitively inhibited microsomal oxidation of ethanol and 1-butanol. The inhibition by the scavengers was specific since these agents had no effect on catalase-dependent oxidation of ethanol, microsomal drug metabolism or microsomal electron transfer. Chemical evidence for production of .OH during microsomal electron transfer was provided by the generation of appropriate products from .OH scavenging agents. H2O2 was shown to play a role as a precursor of .OH. Fe-EDTA increased microsomal oxidation of ethanol without affecting drug metabolism. A role for cytochrome P-450 in catalyzing . OH generation remains to be evaluated. These results suggest that the molecular mechanism underlying the oxidation of ethanol by liver microsomes reflects the ability of ethanol to interact with .OH generated from microsomal electron transfer.
A I Cederbaum, and
E Dicker, and
G Cohen
February 1980,
Archives of biochemistry and biophysics,
A I Cederbaum, and
E Dicker, and
G Cohen
February 2016,
Lipids,
A I Cederbaum, and
E Dicker, and
G Cohen
January 1987,
Annals of the New York Academy of Sciences,
A I Cederbaum, and
E Dicker, and
G Cohen
April 1981,
Biochemical pharmacology,
A I Cederbaum, and
E Dicker, and
G Cohen
October 1997,
Plant physiology,
A I Cederbaum, and
E Dicker, and
G Cohen
April 2010,
Geochemical transactions,
A I Cederbaum, and
E Dicker, and
G Cohen
March 2001,
Journal of inorganic biochemistry,
A I Cederbaum, and
E Dicker, and
G Cohen
January 1985,
Alcoholism, clinical and experimental research,
A I Cederbaum, and
E Dicker, and
G Cohen
April 2024,
Environmental research,
A I Cederbaum, and
E Dicker, and
G Cohen
May 1986,
Experientia,
