-transparent.png){kind=logo}
The mutagenic activity of 5 nitrofuran drugs (furadantin, furoxon, furacin, benzazon VII and lampit) was tested on strains Salmonella typhimurium TA 100, TA 1535, TA 1438 and Escherichia coli WP2 uvrA+ and WP2 wrA. All nitrofurans tested has a marked mutagenic effect on strain TA 100 and, partially, on strain TA 1535 except for furoxon which was strongly toxic for this strain. No significant mutagenic effects of the drugs were observed with strain TA 1538. With the exception of lympit, all drugs exerted a mutagenic action on E coli WP2 vwA but no on WP2 uvA+ which has an intact excision repair system. The only drug exerting a mutagenic effect on the latter strain was furoxon. All five nitrofurans exhibited a positive repair test. The results support the notion that the nitrofuran mutagens under study induce single base substitutions.
L Ebringer, and
M Bencová
January 1984,
Mutation research,
L Ebringer, and
M Bencová
January 1983,
Environmental mutagenesis,
L Ebringer, and
M Bencová
October 1980,
Acta zoologica et pathologica Antverpiensia,
L Ebringer, and
M Bencová
November 1986,
Mutation research,
L Ebringer, and
M Bencová
April 1982,
Mutation research,
L Ebringer, and
M Bencová
July 1959,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
L Ebringer, and
M Bencová
July 1977,
Mutation research,
L Ebringer, and
M Bencová
January 1981,
Progress in food & nutrition science,
L Ebringer, and
M Bencová
August 1986,
Carcinogenesis,
L Ebringer, and
M Bencová
January 1985,
Biomedica biochimica acta,
