BIOMAT Database Logo BIOMAT Database Logo

Enhancement of sister-chromatid exchange in Chinese hamster ovary cells by nitrofurans. 1980

T Shirai, and C Y Wang

The nitrofurans, N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT), N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide (NFTA), 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT), 2-methyl-4-(5-nitro-2-furyl)thiazole (MNFT), 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2), nitrofurantoin, 5-nitro-2-furfurylidene diacetate and 5-nitro-2-furamidoxime were assayed for the enhancement of sister-chromatid exchange (SCE) in Chinese hamster ovary (CHO) cells and for the mutagenic activity in Salmonella typhimurium strain TA100. All of the nitrofurans significantly increased the frequency of SCE in CHO cells, and they were mutagenic for Salmonella. The increases in the frequencies of SCE were well correlated with the mutagenic activities in Salmonella.

UI MeSH Term Description Entries
D009152 Mutagenicity Tests Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests. Genetic Toxicity Tests,Genotoxicity Tests,Mutagen Screening,Tests, Genetic Toxicity,Toxicity Tests, Genetic,Genetic Toxicity Test,Genotoxicity Test,Mutagen Screenings,Mutagenicity Test,Screening, Mutagen,Screenings, Mutagen,Test, Genotoxicity,Tests, Genotoxicity,Toxicity Test, Genetic
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D009581 Nitrofurans Compounds containing FURANS attached to a nitro group.
D010053 Ovary The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE. Ovaries
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D002842 Chromatids Either of the two longitudinally adjacent threads formed when a eukaryotic chromosome replicates prior to mitosis. The chromatids are held together at the centromere. Sister chromatids are derived from the same chromosome. (Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) Chromatid
D003412 Cricetulus A genus of the family Muridae consisting of eleven species. C. migratorius, the grey or Armenian hamster, and C. griseus, the Chinese hamster, are the two species used in biomedical research. Hamsters, Armenian,Hamsters, Chinese,Hamsters, Grey,Armenian Hamster,Armenian Hamsters,Chinese Hamster,Chinese Hamsters,Grey Hamster,Grey Hamsters,Hamster, Armenian,Hamster, Chinese,Hamster, Grey
D003434 Crossing Over, Genetic The reciprocal exchange of segments at corresponding positions along pairs of homologous CHROMOSOMES by symmetrical breakage and crosswise rejoining forming cross-over sites (HOLLIDAY JUNCTIONS) that are resolved during CHROMOSOME SEGREGATION. Crossing-over typically occurs during MEIOSIS but it may also occur in the absence of meiosis, for example, with bacterial chromosomes, organelle chromosomes, or somatic cell nuclear chromosomes. Crossing Over,Crossing-Over, Genetic,Crossing Overs,Genetic Crossing Over,Genetic Crossing-Over
D005260 Female Females
D006224 Cricetinae A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS. Cricetus,Hamsters,Hamster

Related Publications

T Shirai, and C Y Wang
Sister chromatid exchange induced by several types of coffees in Chinese hamster ovary cells.
January 2001, Teratogenesis, carcinogenesis, and mutagenesis,
T Shirai, and C Y Wang
The restriction endonuclease AluI induces sister chromatid exchange in Chinese hamster ovary cells.
July 1992, Mutagenesis,
T Shirai, and C Y Wang
Kinetics of mutation and sister-chromatid exchange induction by ethyl methanesulfonate in Chinese hamster ovary cells.
May 1981, Mutation research,
T Shirai, and C Y Wang
[Sister chromatid exchange in Chinese hamster V79 cells caused by phenacetin].
February 1983, Shigaku = Odontology; journal of Nihon Dental College,
T Shirai, and C Y Wang
Gene mutation and sister chromatid exchange in Chinese hamster cells.
January 1979, Acta biologica Academiae Scientiarum Hungaricae,
T Shirai, and C Y Wang
Sister-chromatid exchange and chromosomal aberrations by DHAQ and related anthraquinone derivatives in Chinese hamster ovary cells.
March 1982, Mutation research,
T Shirai, and C Y Wang
Induction of sister chromatid exchanges in Chinese hamster ovary cells by 5-bromodeoxyuridine.
November 1982, Chemico-biological interactions,
T Shirai, and C Y Wang
compound A induces sister chromatid exchanges in Chinese hamster ovary cells.
April 1997, Anesthesiology,
T Shirai, and C Y Wang
Persistence of sister chromatid exchange by 9-beta-D-arabinofuranosyladenine in Chinese hamster ovary cells cultivated in vitro.
September 1993, Mutagenesis,
T Shirai, and C Y Wang
Computerized image analysis of sister chromatid exchanges in Chinese hamster ovary cells.
October 1997, Mutation research,
Copied contents to your clipboard!