Biomaterial Database

Oral glucose increases urinary albumin excretion in normal subjects but not in insulin-dependent diabetics. 1980

L Hegedüs, and N J Christensen, and C E Mogensen, and H J Gundersen

An oral glucose load increased urinary albumin excretion significantly in six normal subjects (from a mean basal value of 4.6 microgram/min to 16.9 microgram/min at 30-90 min after oral glucose). Urinary excretion of beta-2-microglobulin did not change after oral glucose whereas urinary volume increased. Administration of the water vehicle did not increase albumin excretion. Oral glucose had no effect on urinary albumin excretion in six insulin-dependent diabetics. The effect of oral glucose was not identical to the changes observed after intravenous insulin because oral glucose urinary volume and did not change beta-2-microglobulin excretion whereas insulin decreased both parameters.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D003920	Diabetes Mellitus	A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
D005260	Female		Females
D005951	Glucose Tolerance Test	A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).	Intravenous Glucose Tolerance,Intravenous Glucose Tolerance Test,OGTT,Oral Glucose Tolerance,Oral Glucose Tolerance Test,Glucose Tolerance Tests,Glucose Tolerance, Oral
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000419	Albuminuria	The presence of albumin in the urine, an indicator of KIDNEY DISEASES.	Albuminurias
D001613	beta 2-Microglobulin	An 11-kDa protein associated with the outer membrane of many cells including LYMPHOCYTES. It is the small subunit of MHC CLASS I MOLECULES. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, CEREBROSPINAL FLUID, and urine of healthy individuals, and to a much greater degree in the urine and plasma of patients with tubular PROTEINURIA, renal failure, or kidney transplants.	Thymotaxin,beta 2 Microglobulin
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor