Biomaterial Database

[Effects of gamma-oryzanol and atropine on gastric secretion stimulated by insulin or 2-deoxy-D-glucose (author's transl)]. 1978

K Mizuta, and K Itaya

The inhibitory effects of gamma-oryzanol and atropine on the gastric secretion were studied using insulin and 2-deoxy-D-glucose as vagal stimulants. Pretreatment with gamma-oryzanol (100 mg/kg, s.c., once daily x 5) depressed the gastric secretion stimulated by insulin or 2-deoxy-D-glucose, but the potency was less than that with atropine (10 mg/kg, s.c.). gamma-Oryzanol had no effect on decrease in the serum glucose level or on increase in the gastrin level induced by insulin injection, while atropine enhanced these responses. From these results, it is considered that the inhibitory action of gamma-oryzanol on gastric secretion may be due to depression of the vagus system but the mode of action is different from that of atropine.

UI	MeSH Term	Description	Entries
D007328	Insulin	A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).	Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007329	Insulin Antagonists	Compounds which inhibit or antagonize the biosynthesis or action of insulin.	Antagonists, Insulin
D008297	Male		Males
D010666	Phenylpropionates	Derivatives of 3-phenylpropionic acid, including its salts and esters.
D001786	Blood Glucose	Glucose in blood.	Blood Sugar,Glucose, Blood,Sugar, Blood
D003837	Deoxy Sugars	Sugars that in which one or more hydroxyl groups of the pyranose or furanose ring is substituted by hydrogen.	Deoxy Sugar,Sugar, Deoxy,Sugars, Deoxy
D003847	Deoxyglucose	2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.	2-Deoxy-D-glucose,2-Deoxyglucose,2-Desoxy-D-glucose,2 Deoxy D glucose,2 Deoxyglucose,2 Desoxy D glucose
D005750	Gastric Juice	The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)	Gastric Juices,Juice, Gastric,Juices, Gastric
D005755	Gastrins	A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.	Gastrin
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia