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Two series of patients, randomly selected, 29 of whom had pethidine and 29 of whom had a placebo, were compared in order to study the influence of intra-muscular pethidine on uterine activity and on the speed with which the cervix dilated. The experiment was a double blind one. A significant increase in the basal tone of the uterine muscle was found 40 minutes after the injection in the group that received pethidine, although there was no other significant difference in the other parameters which were intensity, frequency, length, surface of the contractions [half the height multiplied by (X times) the base on the monitor recording], uterine activity in Montevideo and in Toulouse units and the speed of dilatation. These results do not bear out the classical hypotheses of the muscle relaxing effect of pethidine, and in particular that the uterus relaxes better between contractions, nor that there is relaxation of the cervix in labour. The indication for the use of pethidine is perhaps justified because of its analgesic effect, but as far as favouring dilatation of the cervix in labour is concerned is at best worthy of discussion.
M Tournaire, and
D Catinat-Ozil, and
G Bréart, and
P Scherrer, and
J M Baron, and
B Leroy
October 1989,
British journal of obstetrics and gynaecology,
M Tournaire, and
D Catinat-Ozil, and
G Bréart, and
P Scherrer, and
J M Baron, and
B Leroy
January 1979,
Zentralblatt fur Gynakologie,
M Tournaire, and
D Catinat-Ozil, and
G Bréart, and
P Scherrer, and
J M Baron, and
B Leroy
January 1978,
Journal de gynecologie, obstetrique et biologie de la reproduction,
M Tournaire, and
D Catinat-Ozil, and
G Bréart, and
P Scherrer, and
J M Baron, and
B Leroy
October 1980,
Geburtshilfe und Frauenheilkunde,
M Tournaire, and
D Catinat-Ozil, and
G Bréart, and
P Scherrer, and
J M Baron, and
B Leroy
March 1981,
Geburtshilfe und Frauenheilkunde,
M Tournaire, and
D Catinat-Ozil, and
G Bréart, and
P Scherrer, and
J M Baron, and
B Leroy
January 1977,
Ciba Foundation symposium,
M Tournaire, and
D Catinat-Ozil, and
G Bréart, and
P Scherrer, and
J M Baron, and
B Leroy
February 1982,
Ceskoslovenska gynekologie,
M Tournaire, and
D Catinat-Ozil, and
G Bréart, and
P Scherrer, and
J M Baron, and
B Leroy
November 1979,
The Australian & New Zealand journal of obstetrics & gynaecology,
M Tournaire, and
D Catinat-Ozil, and
G Bréart, and
P Scherrer, and
J M Baron, and
B Leroy
January 1979,
Zentralblatt fur Gynakologie,
M Tournaire, and
D Catinat-Ozil, and
G Bréart, and
P Scherrer, and
J M Baron, and
B Leroy
January 1974,
Annales d'histochimie,
