Maximal voluntary isometric contractions of the elevator jaw muscles, with the mandible in the position of maximal intercuspation of the natural teeth, can induce fatigue and weak as well as severe pains in the jaw muscles of children and adults. A subjective sensation of muscle fatigue appears after about 0.5 min of clenching, and it seems as if the psychological parameter of fatigue onset to a large, but unknown, extent is determined by the physiological parameter of the amount of isometric contractile activity, and perhaps also the original strength of the muscle; however, also individual psychological factors seem to play a role. Pains in the elevator jaw muscles appear after about 1 min of clenching. Although isometric contractions are necessary to cause onset of jaw muscle pains, it is conceivable that perception of the moment of onset of pains to a large, but unknown, extent depends on psychological factors, perhaps the intensity of pains; however, also physiological factors may play a role. The severe muscle pains and gradually increasing subjective exhaustion of the elevator jaw muscles can be endured for about 2 min of maximal voluntary tooth clenching. It is suggested that the psychological parameter of muscle endurance to a large, but unknown, extent depends on the physiological parameter of isometric contractile activity but also individual psychological factors seem to play a role.