-transparent.png){kind=logo}
Insulin-induced hypoglycemias are a sign of non-sufficient counterregulation, in which different contra-insulinary hormones participate. The aim of the study was to investigate, whether there exists a difference between IDD and non-diabetics regarding secretion of glucagon, cortisol, and growth hormone during an insulin-induced hypoglycemia and further on pointing out, expecially, the importance of glucagon. Insulin-induced hypoglycemias are counterregulated in non-diabetics, not in IDD. The missing glucagon secretion during insulin-induced hypoglycemia in IDD seems to be independent from an autonomic neuropathy. Only after high doses of exogenous glucagon can one see a counterregulating increase of glucose. The STH secretion is similar in non-diabetics and IDD during an insulin-induced hypoglycemia and has evidently only a secondary effect in hypoglycemic counterregulation. The STH secretion may be the expression of a diencephal-triggered stress situation. The cortisol secretion is the same in both groups. The gluconeogenetic effect of cortisol is not sufficient to accomplish a fast compensation of hypoglycemia. This does not exclude long-term effects. When inhibiting the secretion of insulin and different contra-insulinary hormones with somatostatin, one is able to demonstrate that glucagon alone is a sufficiently counterregulatory hormone in insulin-induced hypoglycemias.
H Drost, and
D Grüneklee, and
H K Kley, and
W Wiegelmann, and
H L Krüskemper, and
F A Gries
February 1986,
Diabete & metabolisme,
H Drost, and
D Grüneklee, and
H K Kley, and
W Wiegelmann, and
H L Krüskemper, and
F A Gries
May 1989,
Orvosi hetilap,
H Drost, and
D Grüneklee, and
H K Kley, and
W Wiegelmann, and
H L Krüskemper, and
F A Gries
November 1986,
Nihon Naibunpi Gakkai zasshi,
H Drost, and
D Grüneklee, and
H K Kley, and
W Wiegelmann, and
H L Krüskemper, and
F A Gries
April 1990,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
H Drost, and
D Grüneklee, and
H K Kley, and
W Wiegelmann, and
H L Krüskemper, and
F A Gries
July 1972,
Klinische Wochenschrift,
H Drost, and
D Grüneklee, and
H K Kley, and
W Wiegelmann, and
H L Krüskemper, and
F A Gries
March 1977,
Diabetes,
H Drost, and
D Grüneklee, and
H K Kley, and
W Wiegelmann, and
H L Krüskemper, and
F A Gries
April 1971,
The Journal of clinical endocrinology and metabolism,
H Drost, and
D Grüneklee, and
H K Kley, and
W Wiegelmann, and
H L Krüskemper, and
F A Gries
September 1993,
The Journal of the Association of Physicians of India,
H Drost, and
D Grüneklee, and
H K Kley, and
W Wiegelmann, and
H L Krüskemper, and
F A Gries
June 1969,
The Journal of clinical endocrinology and metabolism,
H Drost, and
D Grüneklee, and
H K Kley, and
W Wiegelmann, and
H L Krüskemper, and
F A Gries
September 1982,
Diabete & metabolisme,
