-transparent.png){kind=logo}
Five patients with Werner's syndrome were studied to elucidate the relationship between the immune system and the ageing process. Three of five patients had neoplasms such as fibrosarcoma, meningioma and thyroid adenoma but none of the five patients manifested symptoms and signs suggestive of typical autoimmune disorders. Most immunohaematological data were normal; however, two patients exhibited diminished lymphocyte functions such as a significant (P less than 0 . 05) reduction in pokeweed mitogen (PWM) induced B cell differentiation, a slightly decreased response to Con A- or mitomycin-treated allogeneic lymphocytes and naturally occurring serum antibody to T cells. While these immunological changes were quantitatively small, subnormal levels of immune functions were detected. Cultured fibroblasts exhibited a decrease in clonal growth potentials and elongation of newly synthesized DNA, a decreased expression of HLA antigens, and a diminished secretion of beta 2-microglobulin.
Y Nakao, and
T Hattori, and
K Takatsuki, and
Y Kuroda, and
T Nakaji, and
Y Fujiwara, and
M Kishihara, and
Y Baba, and
T Fujita
January 1985,
Advances in experimental medicine and biology,
Y Nakao, and
T Hattori, and
K Takatsuki, and
Y Kuroda, and
T Nakaji, and
Y Fujiwara, and
M Kishihara, and
Y Baba, and
T Fujita
February 1967,
Berufs-Dermatosen,
Y Nakao, and
T Hattori, and
K Takatsuki, and
Y Kuroda, and
T Nakaji, and
Y Fujiwara, and
M Kishihara, and
Y Baba, and
T Fujita
January 1967,
Oftalmologicheskii zhurnal,
Y Nakao, and
T Hattori, and
K Takatsuki, and
Y Kuroda, and
T Nakaji, and
Y Fujiwara, and
M Kishihara, and
Y Baba, and
T Fujita
May 1985,
Archives of dermatology,
Y Nakao, and
T Hattori, and
K Takatsuki, and
Y Kuroda, and
T Nakaji, and
Y Fujiwara, and
M Kishihara, and
Y Baba, and
T Fujita
January 1963,
Acta dermato-venereologica,
Y Nakao, and
T Hattori, and
K Takatsuki, and
Y Kuroda, and
T Nakaji, and
Y Fujiwara, and
M Kishihara, and
Y Baba, and
T Fujita
November 1968,
Wisconsin medical journal,
Y Nakao, and
T Hattori, and
K Takatsuki, and
Y Kuroda, and
T Nakaji, and
Y Fujiwara, and
M Kishihara, and
Y Baba, and
T Fujita
January 1982,
Dermatologica,
Y Nakao, and
T Hattori, and
K Takatsuki, and
Y Kuroda, and
T Nakaji, and
Y Fujiwara, and
M Kishihara, and
Y Baba, and
T Fujita
August 1952,
A.M.A. archives of internal medicine,
Y Nakao, and
T Hattori, and
K Takatsuki, and
Y Kuroda, and
T Nakaji, and
Y Fujiwara, and
M Kishihara, and
Y Baba, and
T Fujita
January 2012,
Indian journal of dermatology, venereology and leprology,
Y Nakao, and
T Hattori, and
K Takatsuki, and
Y Kuroda, and
T Nakaji, and
Y Fujiwara, and
M Kishihara, and
Y Baba, and
T Fujita
June 1996,
The British journal of ophthalmology,
