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Captopril (SQ 14225), an orally active converting enzyme inhibitor, was administered in a dose of 50 mg to 12 normotensive subjects (Group I), 26 essential hypertensive patients (Group II), and 8 renovascular hypertensive patients (Group III). In Group III, 5 of the 8 patients had control plasma renal activity (PRA) similar to those in Groups I and II patients, but the PRA response to the administration of captopril was greater in 7 of the 8 patients than those in Groups I and II. These 7 patients had either bilateral or unilateral main renal artery stenosis. Captopril caused no increase in PRA in the remaining 1 who had unilateral renal artery stenosis with contralateral renin aplasia. It is concluded that this provocation test is useful as a screening procedure for the diagnosis of renovascular hypertension.
Y Imai, and
K Abe, and
Y Otsuka, and
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T Ito, and
M Sato, and
T Haruyama, and
K Omata, and
M Hiwatari, and
K Yoshinaga
May 1989,
American journal of hypertension,
Y Imai, and
K Abe, and
Y Otsuka, and
Y Sakurai, and
T Ito, and
M Sato, and
T Haruyama, and
K Omata, and
M Hiwatari, and
K Yoshinaga
September 1981,
Revista clinica espanola,
Y Imai, and
K Abe, and
Y Otsuka, and
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T Ito, and
M Sato, and
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K Yoshinaga
December 1981,
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Y Imai, and
K Abe, and
Y Otsuka, and
Y Sakurai, and
T Ito, and
M Sato, and
T Haruyama, and
K Omata, and
M Hiwatari, and
K Yoshinaga
September 1981,
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Y Imai, and
K Abe, and
Y Otsuka, and
Y Sakurai, and
T Ito, and
M Sato, and
T Haruyama, and
K Omata, and
M Hiwatari, and
K Yoshinaga
August 1981,
International journal of clinical pharmacology, therapy, and toxicology,
Y Imai, and
K Abe, and
Y Otsuka, and
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T Ito, and
M Sato, and
T Haruyama, and
K Omata, and
M Hiwatari, and
K Yoshinaga
February 1981,
Bollettino della Societa italiana di biologia sperimentale,
Y Imai, and
K Abe, and
Y Otsuka, and
Y Sakurai, and
T Ito, and
M Sato, and
T Haruyama, and
K Omata, and
M Hiwatari, and
K Yoshinaga
September 1978,
Lancet (London, England),
Y Imai, and
K Abe, and
Y Otsuka, and
Y Sakurai, and
T Ito, and
M Sato, and
T Haruyama, and
K Omata, and
M Hiwatari, and
K Yoshinaga
January 1995,
European journal of ophthalmology,
Y Imai, and
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Y Otsuka, and
Y Sakurai, and
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M Sato, and
T Haruyama, and
K Omata, and
M Hiwatari, and
K Yoshinaga
October 1981,
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Y Imai, and
K Abe, and
Y Otsuka, and
Y Sakurai, and
T Ito, and
M Sato, and
T Haruyama, and
K Omata, and
M Hiwatari, and
K Yoshinaga
August 1979,
Canadian Medical Association journal,
