Biomaterial Database

Plaque inhibiting effect of combinations of chlorhexidine and the metal ions zinc and tin. A preliminary report. 1980

S M Wåler, and G Rølla

Rinsing experiments with combinations of chlorhexidine, zinc- and stannous ions were performed in a group of students. Chlorhexidine and zinc (0.2% and 0.3% respectively) gave a plaque inhibiting effect slightly better than chlorhexidine alone, whereas chlorhexidine and stannous ions in the same concentrations showed a reduced effect, presumably due to the low pH of the solution. Pre-rinses with metal ions caused a marked reduction in the effect of chlorhexidine, whereas chlorhexidine first and metal ions afterwards gave approximately the same effect as chlorhexidine alone. The results indicate that the metal ions and chlorhexidine have the same receptor sites in the oral cavity, chlorhexidine exhibiting the stronger affinity when the ions were applied together.

UI	MeSH Term	Description	Entries
D002710	Chlorhexidine	A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.	Chlorhexidine Acetate,Chlorhexidine Hydrochloride,MK-412A,Novalsan,Sebidin A,Tubulicid,Acetate, Chlorhexidine,Hydrochloride, Chlorhexidine,MK 412A,MK412A
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D003773	Dental Plaque	A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.	Plaque, Dental
D004311	Double-Blind Method	A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.	Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014001	Tin	A trace element that is required in bone formation. It has the atomic symbol Sn, atomic number 50, and atomic weight 118.71.	Stannum
D015032	Zinc	A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.