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1. The effects of hydralazine on mean arterial pressure (MAP) heart rate (HR), plasma renin activity (PRA) and plasma catecholamines were examined in conscious rabbits before and after prostaglandin synthesis inhibition with indomethacin. 2. Hydralazine (3 mg/kg. i.v.) produced a 12% decrease in MAP and significant increases in HR, PRA and plasma noradrenaline and adrenaline. 3. Indomethacin (5 mg/kg, s.c.) failed to alter significantly the control MAP, HR, PRA or plasma catecholamines but inhibited renal venous prostaglandin E2 by 56% (P less than 0.02). 4. Indomethacin inhibited the hydralazine-induced tachycardia by 24% and augmented its hypotensive effects by 6%. 5. The hydralazine-stimulated increase in PRA was also inhibited 75% (P less than 0.001) by indomethacin whereas noradrenaline and adrenaline concentrations were not significantly reduced. 6. Indomethacin inhibits hydralazine-induced renin release in the presence of elevated concentrations of plasma catecholamines; these findings suggest that renal prostaglandins function as important mediators of sympathetically-induced renin release.
W B Campbell, and
R M Graham, and
E K Jackson, and
D P Loisel, and
W A Pettinger
June 1981,
The American journal of physiology,
W B Campbell, and
R M Graham, and
E K Jackson, and
D P Loisel, and
W A Pettinger
December 1983,
Life sciences,
W B Campbell, and
R M Graham, and
E K Jackson, and
D P Loisel, and
W A Pettinger
January 1980,
Advances in prostaglandin and thromboxane research,
W B Campbell, and
R M Graham, and
E K Jackson, and
D P Loisel, and
W A Pettinger
January 1967,
Acta medica Scandinavica. Supplementum,
W B Campbell, and
R M Graham, and
E K Jackson, and
D P Loisel, and
W A Pettinger
November 1978,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
W B Campbell, and
R M Graham, and
E K Jackson, and
D P Loisel, and
W A Pettinger
July 1979,
The Journal of pharmacology and experimental therapeutics,
W B Campbell, and
R M Graham, and
E K Jackson, and
D P Loisel, and
W A Pettinger
March 1981,
The American journal of physiology,
W B Campbell, and
R M Graham, and
E K Jackson, and
D P Loisel, and
W A Pettinger
May 1980,
Clinical science (London, England : 1979),
W B Campbell, and
R M Graham, and
E K Jackson, and
D P Loisel, and
W A Pettinger
July 1981,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
W B Campbell, and
R M Graham, and
E K Jackson, and
D P Loisel, and
W A Pettinger
January 1988,
Naunyn-Schmiedeberg's archives of pharmacology,
