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Lysosomal enzymes are released in the blood stream in various types of shock. The role of the released enzymes in the development of irreversible shock is still controversial. The present study was undertaken to determine the effect of the administration of lysosomal enzymes in normal rats and rats treated with endotoxin. Lysosomal enzymes were prepared from the isologous liver. They were given either intravenously or intraperitoneally to normal rats. No hemodynamic effect was observed. They were also given to the rats that received the lethal dose of endotoxin. No hemodynamic effect was found in this group. The survival time and the time course of the blood pressure to death did not change. The lysosomal enzyme preparation was given to the rats that received various dosages of endotoxin of less than LD190. The mortality rate of the rats that received endotoxin was not modified by the administration of the lysosomal enzyme preparation. These results indicate that lysosomal enzymes released into the blood in endotoxin shock may not contribute significantly to the irreversibility of shock.
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