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An unusual cytoplasmic distribution of terminal deoxynucleotidyl transferase (TdT) antigen in leukemic cells from two patients who had chronic myelogenous leukemia in blastic phase is described. In most leukemic cells that contain TdT, the intracellular location has been reported to be exclusively nuclear. The cells from these two patients demonstrated TdT staining in both the nucleus and the cytoplasm. The pattern is remarkably similar to that observed in thymocytes, in which bright cytoplasmic staining may also be seen. In the immunofluorescence procedures for detection of TdT in blasts from patients who have chronic myelogenous leukemia, significant cytoplasmic staining should not be mistaken for nonspecific absorption of immunoglobulins or specimen deterioration.
M L Cibull, and
M S Coleman, and
J J Hutton, and
F J Bollum, and
D V Jackson
January 1979,
Acta haematologica,
M L Cibull, and
M S Coleman, and
J J Hutton, and
F J Bollum, and
D V Jackson
October 1977,
Cancer research,
M L Cibull, and
M S Coleman, and
J J Hutton, and
F J Bollum, and
D V Jackson
October 1976,
Cancer research,
M L Cibull, and
M S Coleman, and
J J Hutton, and
F J Bollum, and
D V Jackson
August 1977,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
M L Cibull, and
M S Coleman, and
J J Hutton, and
F J Bollum, and
D V Jackson
June 1973,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
M L Cibull, and
M S Coleman, and
J J Hutton, and
F J Bollum, and
D V Jackson
May 1978,
Southern medical journal,
M L Cibull, and
M S Coleman, and
J J Hutton, and
F J Bollum, and
D V Jackson
September 1993,
American journal of hematology,
M L Cibull, and
M S Coleman, and
J J Hutton, and
F J Bollum, and
D V Jackson
March 1981,
JAMA,
M L Cibull, and
M S Coleman, and
J J Hutton, and
F J Bollum, and
D V Jackson
September 1983,
Blood,
M L Cibull, and
M S Coleman, and
J J Hutton, and
F J Bollum, and
D V Jackson
January 1984,
Deutsche medizinische Wochenschrift (1946),
