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The effects of dopamine, its precursor L-dopa, and the dopaminergic agonist bromocriptine (BEC), on plasma renin activity (PRA), in pentobarbital anesthetized male dogs were investigated. Infusion of dopamine at a dose which did not change blood pressure ( 4 ug/kg/min) had no effect on the secretion of renin, nor did it produce modifications in the PRA response to furosemide (10 mg i.v.). L-dopa, in single dose of 500 mg (p.o), significantly augmented PRA two hours after administration, and the renin values remained elevated throughout the observation period of 120 minutes. However, BEC (2.5 mg p.o.) produced no changes in PRA during this time period. We conclude that at the dose utilized, dopamine apparently has no influence on the secretion of renin, and does not modify the increase in PRA provoked by diuretic. It is possible that the L-dopa induced augmentation in PRA is due to stimulation of the juxtaglomerular cells, by the noradrenaline formed in peripheral tissues from administered L-dopa.
C Posadas, and
J L Boyer, and
J Guzmán, and
J Figueroa, and
A Millán, and
G Sánchez, and
P A Serrano
August 1975,
European journal of pharmacology,
C Posadas, and
J L Boyer, and
J Guzmán, and
J Figueroa, and
A Millán, and
G Sánchez, and
P A Serrano
September 1964,
The American journal of physiology,
C Posadas, and
J L Boyer, and
J Guzmán, and
J Figueroa, and
A Millán, and
G Sánchez, and
P A Serrano
May 1972,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
C Posadas, and
J L Boyer, and
J Guzmán, and
J Figueroa, and
A Millán, and
G Sánchez, and
P A Serrano
November 1978,
European journal of pharmacology,
C Posadas, and
J L Boyer, and
J Guzmán, and
J Figueroa, and
A Millán, and
G Sánchez, and
P A Serrano
February 1972,
Biochemical pharmacology,
C Posadas, and
J L Boyer, and
J Guzmán, and
J Figueroa, and
A Millán, and
G Sánchez, and
P A Serrano
October 1968,
Japanese circulation journal,
C Posadas, and
J L Boyer, and
J Guzmán, and
J Figueroa, and
A Millán, and
G Sánchez, and
P A Serrano
August 1987,
Experientia,
C Posadas, and
J L Boyer, and
J Guzmán, and
J Figueroa, and
A Millán, and
G Sánchez, and
P A Serrano
December 1971,
British journal of pharmacology,
C Posadas, and
J L Boyer, and
J Guzmán, and
J Figueroa, and
A Millán, and
G Sánchez, and
P A Serrano
August 1978,
Il Farmaco; edizione scientifica,
C Posadas, and
J L Boyer, and
J Guzmán, and
J Figueroa, and
A Millán, and
G Sánchez, and
P A Serrano
January 1977,
Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie,
