Biomaterial Database

Glycogen depletion in exercising rats infused with glucose, lactate, or pyruvate. 1978

G J Bagby, and H J Green, and S Katsuta, and P D Gollnick

The influence of an intravenous infusion of glucose, lactate, or pyruvate on the work capacity and rates of glycogen depletion in the liver and hindlimb skeletal muscles of rats has been studied. Running time to exhaustion at a speed of 21 m/min on a treadmill at a +10 degrees incline was prolonged by glucose infusion but shortened by lactate or pyruvate infusions. Blood glucose concentrations were only lowered in the terminal stages of the exercise, whereas at this point lactate was elevated. Declines in liver and muscle glycogen concentrations were retarded by glucose infusion but accelerated by either lactate or pyruvate infusions. In all cases a marked depletion of both muscle and liver glycogen existed at the point of exhaustion. It is concluded from the lack of any major elevation of glucose, lactate, or pyruvate in the blood of the rats during running that these materials were taken up and oxidized, presumably by the working muscles. These observations suggest that skeletal muscle can take up large amounts of glucose and when it is supplied from an external source this can exert a glycogen sparing effect on the liver and working skeletal muscles.

UI	MeSH Term	Description	Entries
D007263	Infusions, Parenteral	The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.	Intra-Abdominal Infusions,Intraperitoneal Infusions,Parenteral Infusions,Peritoneal Infusions,Infusion, Intra-Abdominal,Infusion, Intraperitoneal,Infusion, Parenteral,Infusion, Peritoneal,Infusions, Intra-Abdominal,Infusions, Intraperitoneal,Infusions, Peritoneal,Intra Abdominal Infusions,Intra-Abdominal Infusion,Intraperitoneal Infusion,Parenteral Infusion,Peritoneal Infusion
D007773	Lactates	Salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D011773	Pyruvates	Derivatives of PYRUVIC ACID, including its salts and esters.
D005082	Physical Exertion	Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.	Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions
D005947	Glucose	A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.	Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D006003	Glycogen
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia