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The ability of clinical isolates of Candida albicans and candida tropicalis to invade through normal and damaged gastrointestinal mucosa was determined. Adult mice were treated with either gentamicin or gentamicin and cytarabine. Suspensions of yeast cells (10(7)) were administered through a catheter intraesophageally. Invasion was determined by culturing liver, kidney, and lung tissue from mice sacrificed after 48 h. C. albicans and C. tropicalis were incapable of invading through normal gastrointestinal mucosa in mice treated only with gentamicin. Two isolates of C. tropicalis penetrated the damaged gastrointestinal mucosa in 69% (49 of 71) of mice treated with gentamicin and cytarabine. In contrast, three isolates of C. albicans penetrated he damaged gastrointestinal mucosa in only 23% (14 of 62) of mice. These results suggest that C. tropicalis is more capable of invading through damaged gastrointestinal mucosa than C. albicans. The observations in this mouse model parallel those seen in patients on cytotoxic drugs. Therefore, this model offers a tool for investigation of the pathogenicity of these organisms in a model analogous to the compromised host.
J R Wingard, and
J D Dick, and
W G Merz, and
G R Sandford, and
R Saral, and
W H Burns
September 2000,
Diagnostic microbiology and infectious disease,
J R Wingard, and
J D Dick, and
W G Merz, and
G R Sandford, and
R Saral, and
W H Burns
November 1992,
Infection and immunity,
J R Wingard, and
J D Dick, and
W G Merz, and
G R Sandford, and
R Saral, and
W H Burns
February 1977,
Bollettino della Societa italiana di biologia sperimentale,
J R Wingard, and
J D Dick, and
W G Merz, and
G R Sandford, and
R Saral, and
W H Burns
February 1981,
Infection and immunity,
J R Wingard, and
J D Dick, and
W G Merz, and
G R Sandford, and
R Saral, and
W H Burns
December 1960,
Canadian Medical Association journal,
J R Wingard, and
J D Dick, and
W G Merz, and
G R Sandford, and
R Saral, and
W H Burns
July 1962,
The Journal of pathology and bacteriology,
J R Wingard, and
J D Dick, and
W G Merz, and
G R Sandford, and
R Saral, and
W H Burns
January 1961,
Sabouraudia,
J R Wingard, and
J D Dick, and
W G Merz, and
G R Sandford, and
R Saral, and
W H Burns
July 1959,
Journal of bacteriology,
J R Wingard, and
J D Dick, and
W G Merz, and
G R Sandford, and
R Saral, and
W H Burns
January 1966,
Acta pathologica et microbiologica Scandinavica,
J R Wingard, and
J D Dick, and
W G Merz, and
G R Sandford, and
R Saral, and
W H Burns
August 1991,
Immunitat und Infektion,
