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The role of the capsular polysaccharide in anaphylactic reactions to Cryptococcus neoformans was investigated. Groups of mice were sensitized with viable cells of either a moderately encapsulated strain of C. neoformans or a non-encapsulated variant. Anaphylactic reactions were observed in both groups of mice to a similar extent when challenged with whole cells. Mice sensitized with the encapsulated strain and challenged with homologous polysaccharide showed only mild hypersensitivity symptoms. Mice sensitized with either the encapsulated or the nonencapsulated strain showed cross-reactivity when challenged with killed cells of the heterologous strain. These data indicate that the capsular polysaccharide plays a minor role in anaphylactic reactions to C. neoformans and that the sensitizing antigen is probably located in the cell wall of the yeast.
Y J Tang, and
R Morelli
September 1978,
Clinical allergy,
Y J Tang, and
R Morelli
November 1961,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
Y J Tang, and
R Morelli
September 1963,
Journal of bacteriology,
Y J Tang, and
R Morelli
September 1961,
Canadian journal of medical technology,
Y J Tang, and
R Morelli
December 1998,
The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society,
Y J Tang, and
R Morelli
February 1993,
Chest,
Y J Tang, and
R Morelli
August 1969,
Giornale italiano di dermatolotia. Minerva dermatologica,
Y J Tang, and
R Morelli
March 1985,
Delaware medical journal,
Y J Tang, and
R Morelli
January 1973,
Lijecnicki vjesnik,
