-transparent.png){kind=logo}
Factors that may influence adherence of Candida albicans to exfoliated human vaginal and buccal epithelial cells were studied in vitro. Factors that enhanced germination enhanced adherence. Heat-killed, germinated Candida organisms demonstrated poorer adherence than viable Candida organisms and no better adherence than nonviable, ungerminated Candida organisms. The difference between adherence of C. albicans to buccal epithelial cells and that to vaginal epithelial cells was significant, as were differences among volunteers. Preincubation in fucose but not mannose, glucose or galactose solutions, preincubation of germinated yeast or of epithelial cells in chymotrypsin or trypsin, a culture supernatant of germinated yeast killed by ultraviolet light, or precoating of epithelial cells with lactobacilli each inhibited adherence. These studies indicate that adherence of C. albicans is enhanced by a surface component of germinated yeast, probably a surface protein that binds to the epithelial receptor, possibly a glycoprotein.
J D Sobel, and
P G Myers, and
D Kaye, and
M E Levison
July 1978,
Infection and immunity,
J D Sobel, and
P G Myers, and
D Kaye, and
M E Levison
August 1984,
Canadian journal of microbiology,
J D Sobel, and
P G Myers, and
D Kaye, and
M E Levison
June 1997,
East African medical journal,
J D Sobel, and
P G Myers, and
D Kaye, and
M E Levison
June 2003,
Revista iberoamericana de micologia,
J D Sobel, and
P G Myers, and
D Kaye, and
M E Levison
April 1984,
Mycopathologia,
J D Sobel, and
P G Myers, and
D Kaye, and
M E Levison
September 1983,
Infection and immunity,
J D Sobel, and
P G Myers, and
D Kaye, and
M E Levison
November 1992,
Arzneimittel-Forschung,
J D Sobel, and
P G Myers, and
D Kaye, and
M E Levison
May 1980,
Infection and immunity,
J D Sobel, and
P G Myers, and
D Kaye, and
M E Levison
December 1983,
The Journal of laboratory and clinical medicine,
J D Sobel, and
P G Myers, and
D Kaye, and
M E Levison
April 2014,
Medical mycology,
