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A randomized, double-blind, controlled trial of insulin and glucagon infusion was conducted in 50 patients with acute alcoholic hepatitis. Twenty-five treatment patients received 24 U regular insulin and 2.4 mg glucagon over 12 h daily for 3 wk. Twenty-five control patients received 200 ml dextrose solution in identical bottles over the same time period. Six control and 2 treatment patients died from liver failure during study, and another treatment patient died from hypoglycemia. In the 34 patients with prothrombin times greater than 3 s prolonged, fewer deaths occurred among the insulin- and glucagon-infused patients (p less than 0.10). Clinical features of liver disease on entry into the study were similar in the two groups, and total serum bilirubin and prothrombin time improved more rapidly in the treatment group (p less than 0.05). Insulin and glucagon infusion is a promising treatment of alcoholic hepatitis and merits further study in the most severely ill patients.
A L Baker, and
J B Jaspan, and
N W Haines, and
G E Hatfield, and
P S Krager, and
J F Schneider
December 1991,
Hepatology (Baltimore, Md.),
A L Baker, and
J B Jaspan, and
N W Haines, and
G E Hatfield, and
P S Krager, and
J F Schneider
January 1992,
Hepatology (Baltimore, Md.),
A L Baker, and
J B Jaspan, and
N W Haines, and
G E Hatfield, and
P S Krager, and
J F Schneider
June 1981,
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A L Baker, and
J B Jaspan, and
N W Haines, and
G E Hatfield, and
P S Krager, and
J F Schneider
October 1987,
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A L Baker, and
J B Jaspan, and
N W Haines, and
G E Hatfield, and
P S Krager, and
J F Schneider
June 2022,
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology,
A L Baker, and
J B Jaspan, and
N W Haines, and
G E Hatfield, and
P S Krager, and
J F Schneider
January 1978,
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion,
A L Baker, and
J B Jaspan, and
N W Haines, and
G E Hatfield, and
P S Krager, and
J F Schneider
February 1992,
The New England journal of medicine,
A L Baker, and
J B Jaspan, and
N W Haines, and
G E Hatfield, and
P S Krager, and
J F Schneider
November 2017,
Seminars in liver disease,
A L Baker, and
J B Jaspan, and
N W Haines, and
G E Hatfield, and
P S Krager, and
J F Schneider
January 1991,
Digestive diseases and sciences,
A L Baker, and
J B Jaspan, and
N W Haines, and
G E Hatfield, and
P S Krager, and
J F Schneider
September 1997,
The American journal of medicine,
