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The acute effect of 20 mg i. v. furosemide on the excretion fraction (EF) of osm, Na, K, and urea was investigated in groups of 32 patients with chronic renal disease and 20 with renal allograft. In renal patients furosemide elicited comparably high increment (delta) of EF osm, Na, and K in both the stage of renal insufficiency and at normal Cin. In transplant patients, the delta EFosm increased in linear relationship to increasing Cin. The different response seems to be attributable to the significance of the correlation of delta EFk to delta EFosm, resp., delta EFNa. The results indicate that in transplant patients the acute effect of furosemide on tubular transport of solutes increases with increasing GFR. This finding could be explained by the influence on potassium excretion.
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