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Examined by flow cytofluorometric analysis, the DNA distribution of EMT 6 tumor cells was highly perturbed after one hour of in vitro incubation with: RPCNU, RFCNU, chlorozotocin (CZT) or 185 (CNCC), four new nitrosourea derivatives. After the treatment with chlorozotocin (20 micrograms/ml) and CNCC (50 micrograms/ml), most of cells were in G2 + M phase and this accumulation lasted more than 48 hours without any restoration before 72 hours. RPCNU (20 micrograms/ml) and RFCNU (50 and 65 micrograms/ml) induced and accumulation of cells in G2 + M phase during 24 hours. The normal state was regained after 48 hours. These reduced rate of progression of the cells through S phase and the G2 block observed after exposure to the new compounds, should, in part, explain their antitumoral activity.
M N Vlaeminck, and
M Collyn-d'Hooghe, and
P Cappelaere, and
G Biserte, and
J Oiry, and
J L Montero, and
J L Imbach
September 1988,
Journal of reproduction and fertility,
M N Vlaeminck, and
M Collyn-d'Hooghe, and
P Cappelaere, and
G Biserte, and
J Oiry, and
J L Montero, and
J L Imbach
July 1982,
New York state journal of medicine,
M N Vlaeminck, and
M Collyn-d'Hooghe, and
P Cappelaere, and
G Biserte, and
J Oiry, and
J L Montero, and
J L Imbach
January 1982,
International journal of radiation oncology, biology, physics,
M N Vlaeminck, and
M Collyn-d'Hooghe, and
P Cappelaere, and
G Biserte, and
J Oiry, and
J L Montero, and
J L Imbach
September 1976,
Acta pathologica et microbiologica Scandinavica. Section A, Pathology,
M N Vlaeminck, and
M Collyn-d'Hooghe, and
P Cappelaere, and
G Biserte, and
J Oiry, and
J L Montero, and
J L Imbach
August 1979,
International journal of radiation oncology, biology, physics,
M N Vlaeminck, and
M Collyn-d'Hooghe, and
P Cappelaere, and
G Biserte, and
J Oiry, and
J L Montero, and
J L Imbach
January 1983,
Cellular and molecular biology,
M N Vlaeminck, and
M Collyn-d'Hooghe, and
P Cappelaere, and
G Biserte, and
J Oiry, and
J L Montero, and
J L Imbach
January 1991,
Pediatric neurology,
M N Vlaeminck, and
M Collyn-d'Hooghe, and
P Cappelaere, and
G Biserte, and
J Oiry, and
J L Montero, and
J L Imbach
January 1987,
Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc,
M N Vlaeminck, and
M Collyn-d'Hooghe, and
P Cappelaere, and
G Biserte, and
J Oiry, and
J L Montero, and
J L Imbach
February 1982,
The Journal of biological chemistry,
M N Vlaeminck, and
M Collyn-d'Hooghe, and
P Cappelaere, and
G Biserte, and
J Oiry, and
J L Montero, and
J L Imbach
May 1982,
Cytometry,
