-transparent.png){kind=logo}
Mutants of Saccharomyces cerevisiae with enhanced sensitivity to the DNA cross-linking agent nitrogen mustard (HN2) have been isolated and partially characterized with respect to their phenotypic and genetic properties. The screening technique, based on HN2-sensitivity as sole criterion, yields approxiamtely 1 sensitive isolate in 200 clones when applied to an intensively mutagenized population of a resistant parent strain. Mutants characterized so far are all due to recessive nuclear genes and represent at least seven complementation groups. They exhibit different degrees as well as different patterns of sensitivity towards monofunctional and bifunctional alkylating agents, and ultraviolet light.
A Ruhland, and
E Haase, and
W Siede, and
M Brendel
November 1981,
Current genetics,
A Ruhland, and
E Haase, and
W Siede, and
M Brendel
May 1986,
Mutation research,
A Ruhland, and
E Haase, and
W Siede, and
M Brendel
March 1991,
Mutation research,
A Ruhland, and
E Haase, and
W Siede, and
M Brendel
December 1965,
Gan,
A Ruhland, and
E Haase, and
W Siede, and
M Brendel
January 1973,
Biophysik,
A Ruhland, and
E Haase, and
W Siede, and
M Brendel
January 2003,
Receptors & channels,
A Ruhland, and
E Haase, and
W Siede, and
M Brendel
April 1987,
Carcinogenesis,
A Ruhland, and
E Haase, and
W Siede, and
M Brendel
February 1994,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
A Ruhland, and
E Haase, and
W Siede, and
M Brendel
August 1966,
Gan,
A Ruhland, and
E Haase, and
W Siede, and
M Brendel
May 1975,
Mutation research,
