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Liver protein synthesis was shown to be enhanced in acute experimental uraemia, when intracellular amino acids were used as substrate. Since protein synthesis also depends on substrate availability and amino acid concentration is higher in uraemic liver cells, it was of interest to investigate the in vitro protein synthesis capacity of isolated liver ribosomes in the presence of standardized amino acids with and without in vivo insulin stimulation. It was demonstrated that protein synthesis capacity of isolated liver ribosomes remains unaltered in acute uraemia and can be stimulated by in vivo insulin application. Our data suggest that in acute uraemia, intracellular substrate availability plays the essential role in impaired liver protein synthesis.
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