Biomaterial Database

Effect of PEEP on gas exchange and pulmonary perfusion in canine lobar pneumonia. 1981

S N Mink, and R B Light, and T Cooligan, and L D Wood

We investigated the effects of positive end-expiratory pressure (PEEP) on respiratory gas exchange and pulmonary perfusion in 10 dogs with left lower lobe (LLL) pneumonia. In 6 dogs, measurements were made with the chest closed and 12 cmH2O were applied; in 4 other open-chest dogs (group O), 6 cmH2O were used. Both groups showed similar changes, and the individual results for all dogs were averaged. With the animals breathing 100% oxygen, total pulmonary shunt (Qs/Qt), arterial oxygen tension (PaO2), and the relative distribution of pulmonary blood flow were measured before, during, and after PEEP. During the control periods, QLLL when expressed as a percent cardiac output averaged 24 +/- 7%. With PEEP, QLLL increased by more than 50% to a mean value of 37 +/- 5%. Despite this increase, the respective values of Qs/Qt and PaO2 improved slightly from 28% and 288 Torr to 25% and 370 Torr. This result suggested that PEEP also improved regional gas exchange, and this finding was subsequently confirmed in Group O where the shunt fractions of the lower lobes were additionally measured. Accordingly, our results show that PEEP altered regional perfusion and shunt so that, on the mean, there was little change in total pulmonary shunt. Whether PEEP worsened or improved gas exchange in any individual experiment was dependent on the relative magnitude of the changes in each of these regional parameters.

UI	MeSH Term	Description	Entries
D008433	Mathematics	The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Mathematic
D011018	Pneumonia, Pneumococcal	A febrile disease caused by STREPTOCOCCUS PNEUMONIAE.	Pneumococcal Pneumonia,Pneumococcal Pneumonias,Pneumonias, Pneumococcal
D011175	Positive-Pressure Respiration	A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.	Positive End-Expiratory Pressure,Positive-Pressure Ventilation,End-Expiratory Pressure, Positive,End-Expiratory Pressures, Positive,Positive End Expiratory Pressure,Positive End-Expiratory Pressures,Positive Pressure Respiration,Positive Pressure Ventilation,Positive-Pressure Respirations,Positive-Pressure Ventilations,Pressure, Positive End-Expiratory,Pressures, Positive End-Expiratory,Respiration, Positive-Pressure,Respirations, Positive-Pressure,Ventilation, Positive-Pressure,Ventilations, Positive-Pressure
D011652	Pulmonary Circulation	The circulation of the BLOOD through the LUNGS.	Pulmonary Blood Flow,Respiratory Circulation,Circulation, Pulmonary,Circulation, Respiratory,Blood Flow, Pulmonary,Flow, Pulmonary Blood,Pulmonary Blood Flows
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004283	Dog Diseases	Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.	Canine Diseases,Canine Disease,Disease, Canine,Disease, Dog,Diseases, Canine,Diseases, Dog,Dog Disease
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia