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The effects of peripheral venous and portal venous delivery of insulin by a closed-loop insulin infusion device (Biostator GCIIS) on postprandial hyperglycemia and rates of glucose appearance, disappearance, and clearance were compared in alloxan-diabetic dogs. The amounts of insulin required and the peripheral venous plasma insulin concentrations achieved were not different for the two routes of insulin administration. No statistically significant differences in postprandial hyperglycemia or patterns of glucose disposal were observed between the two routes of insulin delivery. These studies indicate that in terms of hepatic versus extrahepatic disposal of glucose, there appears to be no practical advantage of portal venous over peripheral venous administration of insulin when a closed-loop insulin infusion device is used.
R A Rizza, and
R E Westland, and
L D Hall, and
G S Patton, and
M W Haymond, and
A H Clemens, and
J E Gerich, and
F J Service
February 1983,
The American journal of physiology,
R A Rizza, and
R E Westland, and
L D Hall, and
G S Patton, and
M W Haymond, and
A H Clemens, and
J E Gerich, and
F J Service
August 1974,
Diabetologia,
R A Rizza, and
R E Westland, and
L D Hall, and
G S Patton, and
M W Haymond, and
A H Clemens, and
J E Gerich, and
F J Service
October 1981,
Endocrinology,
R A Rizza, and
R E Westland, and
L D Hall, and
G S Patton, and
M W Haymond, and
A H Clemens, and
J E Gerich, and
F J Service
July 1956,
Canadian journal of biochemistry and physiology,
R A Rizza, and
R E Westland, and
L D Hall, and
G S Patton, and
M W Haymond, and
A H Clemens, and
J E Gerich, and
F J Service
July 2000,
Metabolism: clinical and experimental,
R A Rizza, and
R E Westland, and
L D Hall, and
G S Patton, and
M W Haymond, and
A H Clemens, and
J E Gerich, and
F J Service
October 1984,
Diabetes,
R A Rizza, and
R E Westland, and
L D Hall, and
G S Patton, and
M W Haymond, and
A H Clemens, and
J E Gerich, and
F J Service
September 1958,
Quarterly journal of studies on alcohol,
R A Rizza, and
R E Westland, and
L D Hall, and
G S Patton, and
M W Haymond, and
A H Clemens, and
J E Gerich, and
F J Service
January 1981,
Canadian journal of physiology and pharmacology,
R A Rizza, and
R E Westland, and
L D Hall, and
G S Patton, and
M W Haymond, and
A H Clemens, and
J E Gerich, and
F J Service
June 1948,
Nature,
R A Rizza, and
R E Westland, and
L D Hall, and
G S Patton, and
M W Haymond, and
A H Clemens, and
J E Gerich, and
F J Service
July 1980,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
