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Intravenous glucose infusion was performed in six dogs with and without truncal vagotomy, and plasma pancreatic polypeptide (PP) responses were compared before and after truncal vagotomy. Following truncal vagotomy, basal PP levels decreased significantly from 286 +/- 64 pg/ml (mean +/- S.E.) to 94 +/- 14 pg/ml (P less than 0.05). Basal plasma insulin and blood glucose levels also tended to be lower, but not significantly. During the infusion of glucose, blood glucose concentrations rose rapidly in both groups and after 15 min reached peak values which were not significantly different from each other. In the vagotomized group the plasma insulin response to intravenous glucose infusion was significantly lower than in the control group. Following intravenous glucose loading, plasma PP concentrations decreased rapidly in both groups, but the PP level in the vagotomized group was suppressed only to 77 +/- 4% of the basal level whereas in the control group it decreased by 45 +/- 8%, significantly lower than in the vagotomized group (P less than 0.01). These results suggest that basal PP is regulated by vagal tonus and that vagus controls, at least in part, suppression by intravenous glucose administration.
K Tsuda, and
Y Seino, and
K Mori, and
S Seino, and
J Takemura, and
H Kuzuya, and
T Yamamura, and
Y Kotoura, and
N Ito, and
H Imura
August 1995,
Regulatory peptides,
K Tsuda, and
Y Seino, and
K Mori, and
S Seino, and
J Takemura, and
H Kuzuya, and
T Yamamura, and
Y Kotoura, and
N Ito, and
H Imura
January 1975,
Scandinavian journal of gastroenterology,
K Tsuda, and
Y Seino, and
K Mori, and
S Seino, and
J Takemura, and
H Kuzuya, and
T Yamamura, and
Y Kotoura, and
N Ito, and
H Imura
June 1988,
Surgery,
K Tsuda, and
Y Seino, and
K Mori, and
S Seino, and
J Takemura, and
H Kuzuya, and
T Yamamura, and
Y Kotoura, and
N Ito, and
H Imura
September 1987,
American journal of surgery,
K Tsuda, and
Y Seino, and
K Mori, and
S Seino, and
J Takemura, and
H Kuzuya, and
T Yamamura, and
Y Kotoura, and
N Ito, and
H Imura
May 1985,
The American journal of physiology,
K Tsuda, and
Y Seino, and
K Mori, and
S Seino, and
J Takemura, and
H Kuzuya, and
T Yamamura, and
Y Kotoura, and
N Ito, and
H Imura
September 1984,
Khirurgiia,
K Tsuda, and
Y Seino, and
K Mori, and
S Seino, and
J Takemura, and
H Kuzuya, and
T Yamamura, and
Y Kotoura, and
N Ito, and
H Imura
January 1973,
Scandinavian journal of gastroenterology,
K Tsuda, and
Y Seino, and
K Mori, and
S Seino, and
J Takemura, and
H Kuzuya, and
T Yamamura, and
Y Kotoura, and
N Ito, and
H Imura
June 1982,
Scandinavian journal of gastroenterology,
K Tsuda, and
Y Seino, and
K Mori, and
S Seino, and
J Takemura, and
H Kuzuya, and
T Yamamura, and
Y Kotoura, and
N Ito, and
H Imura
January 1984,
Digestion,
K Tsuda, and
Y Seino, and
K Mori, and
S Seino, and
J Takemura, and
H Kuzuya, and
T Yamamura, and
Y Kotoura, and
N Ito, and
H Imura
November 1982,
American journal of surgery,
