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Penbutolol, a new beta-adrenoceptor blocker, was found to increase the glomerular filtration rate (GFR) significantly (16%) relative to placebo when administered orally in a dose of 40 mg daily for 7 consecutive days to healthy males. Measurements were performed after the seventh dose. In contrast, a single acute intravenous dose of penbutolol 4 mg did not influence the GFR, which was determined by means of a gamma counter after intravenous injection of technetium-99m diethylenetriaminepenta-acetic acid. Since penbutolol possesses moderate beta-adrenomimetic activity, it is postulated that the observed increase in the GFR after oral penbutolol could be due to increased cardiac output at rest.
B H Meyer, and
F O Müller, and
M G Lötter, and
M P Iturralde, and
H G Grigoleit
July 1973,
The Journal of surgical research,
B H Meyer, and
F O Müller, and
M G Lötter, and
M P Iturralde, and
H G Grigoleit
October 2006,
BJU international,
B H Meyer, and
F O Müller, and
M G Lötter, and
M P Iturralde, and
H G Grigoleit
October 1986,
British journal of clinical pharmacology,
B H Meyer, and
F O Müller, and
M G Lötter, and
M P Iturralde, and
H G Grigoleit
October 1978,
Clinical science and molecular medicine,
B H Meyer, and
F O Müller, and
M G Lötter, and
M P Iturralde, and
H G Grigoleit
January 1975,
Contributions to nephrology,
B H Meyer, and
F O Müller, and
M G Lötter, and
M P Iturralde, and
H G Grigoleit
August 1983,
The American journal of psychiatry,
B H Meyer, and
F O Müller, and
M G Lötter, and
M P Iturralde, and
H G Grigoleit
May 1984,
The British journal of radiology,
B H Meyer, and
F O Müller, and
M G Lötter, and
M P Iturralde, and
H G Grigoleit
July 2001,
Clinical nephrology,
B H Meyer, and
F O Müller, and
M G Lötter, and
M P Iturralde, and
H G Grigoleit
January 1983,
The New England journal of medicine,
B H Meyer, and
F O Müller, and
M G Lötter, and
M P Iturralde, and
H G Grigoleit
March 1966,
Voprosy okhrany materinstva i detstva,
