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Standard tests and two enzyme-linked immunosorbent assays (ELISAs) were compared for detecting systemic candidiasis in 92 leukemic patients. Antibodies to Candida were detected by immunodiffusion (ID), latex agglutination (LA), and indirect ELISA; antigenemia was evaluated by indirect ELISA inhibition. In 48 patients without candidiasis (group 1), sera from 27% reacted in ID and 13% in LA tests; titers of antibody by ELISA occurred in all patients. In 34 patients without disseminated candidiasis (groups 2 and 3), Candida species were isolated; sera from 35% and 32% were positive in the ID and the LA test, respectively. In nine of 10 patients with disseminated candidiasis (group 4), LA and ID tests were negative. Seven patients in groups 1-3 without disseminated candidiasis were antigenemic (false-positive rate, 9%). Antigenemia was detected in seven of 10 patients with disseminated candidiasis; in the remaining three patients sera were drawn too early to be of diagnostic value. Thus, monitoring of immunosuppressed patients for mannan antigenemia is useful for the detection of disseminated candidiasis.
K L Meckstroth, and
E Reiss, and
J W Keller, and
L Kaufman
June 1980,
The Journal of laboratory and clinical medicine,
K L Meckstroth, and
E Reiss, and
J W Keller, and
L Kaufman
March 1986,
Journal of clinical microbiology,
K L Meckstroth, and
E Reiss, and
J W Keller, and
L Kaufman
January 1993,
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc,
K L Meckstroth, and
E Reiss, and
J W Keller, and
L Kaufman
October 1979,
Journal of clinical microbiology,
K L Meckstroth, and
E Reiss, and
J W Keller, and
L Kaufman
January 1985,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
K L Meckstroth, and
E Reiss, and
J W Keller, and
L Kaufman
October 1988,
The Journal of laboratory and clinical medicine,
K L Meckstroth, and
E Reiss, and
J W Keller, and
L Kaufman
January 2005,
Methods in molecular biology (Clifton, N.J.),
K L Meckstroth, and
E Reiss, and
J W Keller, and
L Kaufman
April 1982,
Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology,
K L Meckstroth, and
E Reiss, and
J W Keller, and
L Kaufman
April 1983,
Experimental parasitology,
K L Meckstroth, and
E Reiss, and
J W Keller, and
L Kaufman
November 1992,
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica,
