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The effect of dietary vitamin C on vitamin E status and function was studied with weanling male Hartley guinea pigs. Thirty guinea pigs fed a basal diet free of vitamins E and C were divided into two groups; only one group received 2 mg/100 g body weight/day of vitamin C. Each group was further divided into three subgroups and received 0, 0.2, and 0.4 IU/100 g body weight/day of vitamin E. After 5 weeks the animals were killed. Degree of erythrocyte hemolysis induced by dialuric acid, level of plasma vitamin E and extent of liver lipid peroxidation were determined. Liver mitochondria were isolated and in vitro oxygen uptake was measured. The rate of swelling of mitochondria in two media was also determined. The results showed that the adequate dietary vitamin C supplementation did not affect the extent of erythrocyte hemolysis induced by dialuric acid, but increased the plasma vitamin E level and lowered liver lipid peroxidation. It also maintained the normal respiration and swelling rates of liver mitochondria when vitamin E was inadequate.
L H Chen, and
M L Chang
March 1959,
The Biochemical journal,
L H Chen, and
M L Chang
September 1984,
The Journal of nutrition,
L H Chen, and
M L Chang
September 1996,
Lipids,
L H Chen, and
M L Chang
February 1978,
Lipids,
L H Chen, and
M L Chang
March 1975,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
L H Chen, and
M L Chang
January 1992,
In vivo (Athens, Greece),
L H Chen, and
M L Chang
January 1982,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
L H Chen, and
M L Chang
May 1961,
Nature,
L H Chen, and
M L Chang
January 1965,
Tsitologiia,
L H Chen, and
M L Chang
January 1953,
Journal de physiologie,
