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The dorsal horn of the mammalian spinal cord contains interneurones which synthetize opioid peptides (endorphins) and release them on synaptic activation. Cells of origin of the spino-thalamic tract are in close functional relationship with these interneurones. The activation of the postulated endorphinergic mechanisms in the spinal cord could explain the selective reduction of painful stimuli following epidural application of opiate agonist.
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