Biomaterial Database

Responses of denervated adult newt limb stumps to reinnervation and reinjury. 1981

J D Salley, and R A Tassava

It is well known that denervated adults newt limbs do not regenerate. Not understood is why denervated newt limb stumps fail to initiate regeneration upon reinnervation. In an effort to define the regeneration limiting factors, we examined the histology of long-term denervated newt limb stumps and tested the effects of various kinds of reinjury. In 5-week denervated limb stumps there were present dedifferentiated cells, differentiated cartilage, and densely packed layered cells. The epidermis covering the limb tip resembled skin epidermis rather than wound epidermis. The kinds of reinjury that were successful in restoring the regeneration capabilities to 5-week denervated limb stumps included; reamputation (100%), a single razor incision (60%), and removal of the healed tissues from the distal limb tip (70%). The results of the study emphasize the importance of both injury and wound epidermis in initiating regeneration.

UI	MeSH Term	Description	Entries
D012038	Regeneration	The physiological renewal, repair, or replacement of tissue.	Endogenous Regeneration,Regeneration, Endogenous,Regenerations
D003714	Denervation	The resection or removal of the nerve to an organ or part.	Laser Neurectomy,Neurectomy,Peripheral Neurectomy,Radiofrequency Neurotomy,Denervations,Laser Neurectomies,Neurectomies,Neurectomies, Laser,Neurectomies, Peripheral,Neurectomy, Laser,Neurectomy, Peripheral,Neurotomies, Radiofrequency,Neurotomy, Radiofrequency,Peripheral Neurectomies,Radiofrequency Neurotomies
D005121	Extremities	The farthest or outermost projections of the body, such as the HAND and FOOT.	Limbs,Extremity,Limb
D000672	Amputation Stumps	The part of a limb or tail following AMPUTATION, SURGICAL that is proximal to the amputated section.	Amputation Stump,Stump, Amputation,Stumps, Amputation
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012455	Salamandridae	A family of Urodela consisting of 15 living genera and about 42 species and occurring in North America, Europe, Asia, and North Africa.	Newts,Taricha,Newt,Tarichas
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D016038	Skin Transplantation	The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.	Dermatoplasty,Grafting, Skin,Transplantation, Skin,Dermatoplasties,Graftings, Skin,Skin Grafting,Skin Graftings,Skin Transplantations,Transplantations, Skin