-transparent.png){kind=logo}
Total hemolytic complement activity (CH50), immuno-electrophoretic conversion of Factor B (C3PA), and of C3 were studied in 16 patients with sickle cell disease in a steady state, eight patients in crisis, and ten patients with β-thalassemia major anemia maintained on a constant transfusion regimen. Patients with sickle cell disease in a steady state have moderatley 56 (percent) depressed conversion of Factor B in addition to markedly decreased conversion of C3 in four of ten patients. One of the three sickle cell patients and two of the four thalassemia patients with low C3 conversion levels have died subsequent to the studies. The combination of chronically decreased Factor B conversion in the face of markedly decreased C3 conversion may make these patients occasionally vulnerable to overwhelming infection analagous to the situation seen in postsplenectomy cases.
A C deCiutiis, and
C M Peterson, and
M J Polley, and
L J Metakis
January 1991,
NAACOG's clinical issues in perinatal and women's health nursing,
A C deCiutiis, and
C M Peterson, and
M J Polley, and
L J Metakis
February 1994,
Human genetics,
A C deCiutiis, and
C M Peterson, and
M J Polley, and
L J Metakis
November 2008,
Current molecular medicine,
A C deCiutiis, and
C M Peterson, and
M J Polley, and
L J Metakis
October 1985,
Clinical immunology and immunopathology,
A C deCiutiis, and
C M Peterson, and
M J Polley, and
L J Metakis
December 1976,
JAMA,
A C deCiutiis, and
C M Peterson, and
M J Polley, and
L J Metakis
May 1973,
Die Medizinische Welt,
A C deCiutiis, and
C M Peterson, and
M J Polley, and
L J Metakis
January 1982,
Birth defects original article series,
A C deCiutiis, and
C M Peterson, and
M J Polley, and
L J Metakis
December 1963,
Blood,
A C deCiutiis, and
C M Peterson, and
M J Polley, and
L J Metakis
December 1968,
American journal of diseases of children (1960),
A C deCiutiis, and
C M Peterson, and
M J Polley, and
L J Metakis
June 1981,
American journal of diseases of children (1960),
