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To investigate the role of renal prostaglandin in the regulation of sodium metabolism, ruinary prostaglandin E excretion, an indicator of renal prostaglandin synthesis, urinary sodium excretion, plasma renin activity and urinary aldosterone excretion were measured in 84 normal subjects and 55 patients with essential hypertension on ad lib intake of sodium. The excretion rates of urinary prostaglandin E were 736.8 +/- 32.2 ng/day in normal subjects and 394.3 +/- 28.7 ng/day in essential hypertensives. The excretion rate was significantly decreased in essential hypertensives (P less than 0.001). A significant positive correlation was found between urinary sodium excretion and urinary prostaglandin E excretion in normal subjects (r = 0.39, P less than 0.001), and in essential hypertensives (r = 0.62, P less than 0.001). There was no correlation between the renin-angiotensin-aldosterone system and urinary prostaglandin E excretion in normal subjects as well as in essential hypertensives. The present data show that renal prostaglandin might be involved in the renal handling of sodium, and prove the possibility that the decrease of renal prostaglandin synthesis is one of the etiological factors in essential hypertension.
M Yasujima, and
K Abe, and
S Chiba, and
M Sato, and
N Irokawa, and
M Seino, and
Y Imai, and
K Saito, and
Y Sakurai, and
T Ito, and
T Haruyama, and
K Ritsu, and
K Yoshinaga
October 1976,
Experientia,
M Yasujima, and
K Abe, and
S Chiba, and
M Sato, and
N Irokawa, and
M Seino, and
Y Imai, and
K Saito, and
Y Sakurai, and
T Ito, and
T Haruyama, and
K Ritsu, and
K Yoshinaga
October 1978,
Prostaglandins,
M Yasujima, and
K Abe, and
S Chiba, and
M Sato, and
N Irokawa, and
M Seino, and
Y Imai, and
K Saito, and
Y Sakurai, and
T Ito, and
T Haruyama, and
K Ritsu, and
K Yoshinaga
May 1980,
Prostaglandins and medicine,
M Yasujima, and
K Abe, and
S Chiba, and
M Sato, and
N Irokawa, and
M Seino, and
Y Imai, and
K Saito, and
Y Sakurai, and
T Ito, and
T Haruyama, and
K Ritsu, and
K Yoshinaga
January 1987,
Contributions to nephrology,
M Yasujima, and
K Abe, and
S Chiba, and
M Sato, and
N Irokawa, and
M Seino, and
Y Imai, and
K Saito, and
Y Sakurai, and
T Ito, and
T Haruyama, and
K Ritsu, and
K Yoshinaga
May 1978,
Acta physiologica Scandinavica,
M Yasujima, and
K Abe, and
S Chiba, and
M Sato, and
N Irokawa, and
M Seino, and
Y Imai, and
K Saito, and
Y Sakurai, and
T Ito, and
T Haruyama, and
K Ritsu, and
K Yoshinaga
April 1981,
Japanese journal of pharmacology,
M Yasujima, and
K Abe, and
S Chiba, and
M Sato, and
N Irokawa, and
M Seino, and
Y Imai, and
K Saito, and
Y Sakurai, and
T Ito, and
T Haruyama, and
K Ritsu, and
K Yoshinaga
January 1980,
Biology of the neonate,
M Yasujima, and
K Abe, and
S Chiba, and
M Sato, and
N Irokawa, and
M Seino, and
Y Imai, and
K Saito, and
Y Sakurai, and
T Ito, and
T Haruyama, and
K Ritsu, and
K Yoshinaga
October 1987,
Prostaglandins,
M Yasujima, and
K Abe, and
S Chiba, and
M Sato, and
N Irokawa, and
M Seino, and
Y Imai, and
K Saito, and
Y Sakurai, and
T Ito, and
T Haruyama, and
K Ritsu, and
K Yoshinaga
April 1983,
Nihon Jinzo Gakkai shi,
M Yasujima, and
K Abe, and
S Chiba, and
M Sato, and
N Irokawa, and
M Seino, and
Y Imai, and
K Saito, and
Y Sakurai, and
T Ito, and
T Haruyama, and
K Ritsu, and
K Yoshinaga
January 1980,
Prostaglandins and medicine,
