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After a brief account of the laboratory and animal studies of 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2-aminoethanol salt (ciclopiroxolamine, Cic, Hoe 296, Batrafen) and an outline of previous clinical trials, the results of a double-blind trial with Cic cream and clotrimazole cream are reported, together with those of a large-scale trial of Cic cream in consulting practice. Used for the treatment of skin disorders diagnosed as mycoses, the effectiveness rate of Cic cream ranged from 79 to 98%, depending on the criterion used for assessment. The double-blind trial did not reveal any significant differences between its effect and that of clotrimazole cream. The incidence of side-effects can be regarded as minimal.
W Adam, and
H G Peil, and
C Savopoulos, and
O Vanderbeke
January 1981,
Arzneimittel-Forschung,
W Adam, and
H G Peil, and
C Savopoulos, and
O Vanderbeke
January 1986,
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia,
W Adam, and
H G Peil, and
C Savopoulos, and
O Vanderbeke
August 1976,
Tijdschrift voor diergeneeskunde,
W Adam, and
H G Peil, and
C Savopoulos, and
O Vanderbeke
August 1968,
Mykosen,
W Adam, and
H G Peil, and
C Savopoulos, and
O Vanderbeke
July 1979,
Mykosen,
W Adam, and
H G Peil, and
C Savopoulos, and
O Vanderbeke
January 1981,
Arzneimittel-Forschung,
W Adam, and
H G Peil, and
C Savopoulos, and
O Vanderbeke
June 1976,
Ceskoslovenska dermatologie,
W Adam, and
H G Peil, and
C Savopoulos, and
O Vanderbeke
July 1978,
Deutsche medizinische Wochenschrift (1946),
W Adam, and
H G Peil, and
C Savopoulos, and
O Vanderbeke
January 1981,
Arzneimittel-Forschung,
W Adam, and
H G Peil, and
C Savopoulos, and
O Vanderbeke
January 1981,
Arzneimittel-Forschung,
