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To study the mechanism of hyperinsulinism and glucose intolerance in liver disease, insulin removal rate by liver and muscle, glucose uptake by muscle and insulin secretion from pancreas were measured using the perfusion in rats with injured liver induced by carbon tetrachloride (liver injury rat). In the perfused liver, insulin removal rate of liver injury rat decreased to 62% of that of normal rat, but it did not alter in the perfused muscle. Insulin response to arginine by the perfused pancreas of liver injury rat was similar to that of normal rat. Before insulin infusion, glucose uptake by the perfused muscle was similar in liver injury rat and normal rat. In contrast, during insulin infusion, glucose uptake by the perfused muscle was 1.5 times higher in liver injury rat than in normal rat. These results suggested that the peripheral hyperinsulinism was solely due to decreased hepatic insulin degradation, but not hypersecretion of insulin from pancreas and furthermore, might suggest that the insulin resistance was related to appearance of biologically inactive endogenous insulin, because of exogenous insulin completely acting on peripheral target tissue.
S Sasaki, and
N Masaki, and
H Yashiro, and
M Kudo, and
K Kimura, and
K Takebe
April 1979,
The American journal of physiology,
S Sasaki, and
N Masaki, and
H Yashiro, and
M Kudo, and
K Kimura, and
K Takebe
January 1976,
Acta biologica et medica Germanica,
S Sasaki, and
N Masaki, and
H Yashiro, and
M Kudo, and
K Kimura, and
K Takebe
September 1968,
Endocrinology,
S Sasaki, and
N Masaki, and
H Yashiro, and
M Kudo, and
K Kimura, and
K Takebe
August 1971,
The Tohoku journal of experimental medicine,
S Sasaki, and
N Masaki, and
H Yashiro, and
M Kudo, and
K Kimura, and
K Takebe
June 1970,
Diabetes,
S Sasaki, and
N Masaki, and
H Yashiro, and
M Kudo, and
K Kimura, and
K Takebe
September 1969,
Endocrinology,
S Sasaki, and
N Masaki, and
H Yashiro, and
M Kudo, and
K Kimura, and
K Takebe
July 1976,
Endocrinology,
S Sasaki, and
N Masaki, and
H Yashiro, and
M Kudo, and
K Kimura, and
K Takebe
December 1980,
Canadian journal of physiology and pharmacology,
S Sasaki, and
N Masaki, and
H Yashiro, and
M Kudo, and
K Kimura, and
K Takebe
June 1982,
The American journal of physiology,
S Sasaki, and
N Masaki, and
H Yashiro, and
M Kudo, and
K Kimura, and
K Takebe
January 1980,
Acta endocrinologica,
