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We describe the modification of the side chain of the arginine-B22 residue of insulin by the N8N9-(1, 2-dihydroxycyclohex-1,2-ylene) group and by the adipoyl group. These are the first insulin derivatives described that contain a modified arginine residue in an otherwise unaltered molecule. When tested for their ability to lower blood sugar concentration, both modified insulins showed a specific activity indistinguishable from that of insulin. In view of the fact that the substituent groups involved are very bulky and in one case of opposite charge to that of the side chain, the retention of biological activity casts doubt on the idea, previously generally accepted, that the arginine-B22 residue is essential to the activity of the hormone.
K Rose, and
A R Rees, and
C S Drake, and
R E Offord
December 1977,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
K Rose, and
A R Rees, and
C S Drake, and
R E Offord
December 1982,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
K Rose, and
A R Rees, and
C S Drake, and
R E Offord
February 1981,
Scientia Sinica,
K Rose, and
A R Rees, and
C S Drake, and
R E Offord
August 1971,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
K Rose, and
A R Rees, and
C S Drake, and
R E Offord
August 2006,
Acta biochimica et biophysica Sinica,
K Rose, and
A R Rees, and
C S Drake, and
R E Offord
April 1980,
Indian journal of biochemistry & biophysics,
K Rose, and
A R Rees, and
C S Drake, and
R E Offord
July 2023,
Chemical science,
K Rose, and
A R Rees, and
C S Drake, and
R E Offord
June 1981,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
K Rose, and
A R Rees, and
C S Drake, and
R E Offord
February 2001,
Biochemistry,
K Rose, and
A R Rees, and
C S Drake, and
R E Offord
June 2011,
FEBS letters,
