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The antibody specificity of immunoglobulin G bound to the liver cell membrane during hepatitis B virus infection and chronic liver disease has been studied in 8 patients after antibody elution with high molar urea. Eluted immunoglobulin G showed antibody specificity for hepatitis B core antigen by radioimmunoassay and by indirect immunofluorescence on positive liver tissue. On the contrary, no reaction could be detected against other viral antigens (i.e., hepatitis B surface antigen and hepatitis B e antigen) or against liver-specific proteins. Furthermore, in 5 selected cases, after urea removal of cytophilic antibody, hepatitis B core antigen could be demonstrated by direct immunofluorescence in a granular pattern on the liver cell surface, thus suggesting a masking effect of immunoglobulin G on membranous hepatitis B core antigen in patients with persistent virus replication in the liver.
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