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This report describes the use of an in vivo 51Cr release assay which is able to monitor various immune reactions in the rat. This assay is able to quantitate the immune response to tumour and also to assess the relative efficacy of different immunostimulants in this tumour model. These data correlate well with survival studies in tumour-bearing rats. This assay can also measure the sensitizing effect of antigens from animals differing at both the major and minor histocompatibility locus using various routes of sensitization and various donor tissues. Allograft survival can also be correlated to in vivo 51Cr release. This method is both reproducible and specific. The in vivo 51Cr release assay is a useful and versatile means of monitoring the development of antitumour responses and the degree of sensitization to histocompatibility antigens in a variety of situations in the rat. It may therefore prove useful as a rapid method for screening new antitumour and immunosuppressive regimens to be used in various studies.
L Makowka, and
R E Falk, and
J A Falk, and
J Teodorczyk-Injeyan, and
N A Nossal, and
L E Rotstein
October 1975,
Journal of immunological methods,
L Makowka, and
R E Falk, and
J A Falk, and
J Teodorczyk-Injeyan, and
N A Nossal, and
L E Rotstein
January 1970,
Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology,
L Makowka, and
R E Falk, and
J A Falk, and
J Teodorczyk-Injeyan, and
N A Nossal, and
L E Rotstein
June 1974,
Transplantation,
L Makowka, and
R E Falk, and
J A Falk, and
J Teodorczyk-Injeyan, and
N A Nossal, and
L E Rotstein
January 1986,
Allergie und Immunologie,
L Makowka, and
R E Falk, and
J A Falk, and
J Teodorczyk-Injeyan, and
N A Nossal, and
L E Rotstein
July 1994,
Clinical and experimental pharmacology & physiology,
L Makowka, and
R E Falk, and
J A Falk, and
J Teodorczyk-Injeyan, and
N A Nossal, and
L E Rotstein
August 1977,
Cellular immunology,
L Makowka, and
R E Falk, and
J A Falk, and
J Teodorczyk-Injeyan, and
N A Nossal, and
L E Rotstein
May 1956,
Clinical science,
L Makowka, and
R E Falk, and
J A Falk, and
J Teodorczyk-Injeyan, and
N A Nossal, and
L E Rotstein
March 1966,
Transplantation,
L Makowka, and
R E Falk, and
J A Falk, and
J Teodorczyk-Injeyan, and
N A Nossal, and
L E Rotstein
January 1980,
Folia biologica,
L Makowka, and
R E Falk, and
J A Falk, and
J Teodorczyk-Injeyan, and
N A Nossal, and
L E Rotstein
July 1986,
Clinical science (London, England : 1979),
