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To determine if dose spacing of low dose chronic suppressive corticosteroid therapy would result in different effects on circulating T lymphocytes and hypothalamic-pituitary-adrenal (HPA) axis suppression, a crossover trial of two maintenance steroid regimens was performed. Twenty stable renal allograft recipients were treated for 6 mo with daily prednisone (DS) and then the same patients were abruptly converted to alternate-day prednisone (ADS) for another 6 mo. Total prednisone dosage was identical during the 6-mo study periods and only dose spacing differed. Both circulating T lymphocyte numbers and responsiveness to mitogens were less on the DS regimen. Patients gained weight on DS and lost weight on ADS. Five of the 20 patients developed infections on DS. However, HPA suppression was not different on the two regimens. These findings suggest that dose spacing alters the immunosuppressive and metabolic response to prednisone, even at low dose.
J J Curtis, and
J H Galla, and
S Y Woodford, and
R J Saykaly, and
R G Luke
October 1969,
The New England journal of medicine,
J J Curtis, and
J H Galla, and
S Y Woodford, and
R J Saykaly, and
R G Luke
June 1991,
Archives of neurology,
J J Curtis, and
J H Galla, and
S Y Woodford, and
R J Saykaly, and
R G Luke
November 1985,
Chest,
J J Curtis, and
J H Galla, and
S Y Woodford, and
R J Saykaly, and
R G Luke
July 1998,
Clinical pediatrics,
J J Curtis, and
J H Galla, and
S Y Woodford, and
R J Saykaly, and
R G Luke
May 1975,
Annals of internal medicine,
J J Curtis, and
J H Galla, and
S Y Woodford, and
R J Saykaly, and
R G Luke
January 1976,
Annals of the New York Academy of Sciences,
J J Curtis, and
J H Galla, and
S Y Woodford, and
R J Saykaly, and
R G Luke
August 1995,
Clinical transplantation,
J J Curtis, and
J H Galla, and
S Y Woodford, and
R J Saykaly, and
R G Luke
May 2002,
Blood,
J J Curtis, and
J H Galla, and
S Y Woodford, and
R J Saykaly, and
R G Luke
April 1991,
The American journal of gastroenterology,
J J Curtis, and
J H Galla, and
S Y Woodford, and
R J Saykaly, and
R G Luke
October 1987,
The Journal of allergy and clinical immunology,
