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To assess the efficacy of a new calcium entry blocker, diltiazem (Cardizem), for prophylaxis of Prinzmetal's angina, 48 patients were studied in randomized, multiple crossover multiclinic study (2 weeks single-blind, 8 weeks double-blind). Diltiazem dosage in one crossover phase was 120 mg per day; in the other, 240 mg per day. Therapeutic response was measured by patients' diary records of angina frequency and nitroglycerin tablet consumption. Treatment with 120 mg of diltiazem per day reduced angina by 41 percent from the entry placebo period and 20 percent from the paired placebo period (p less than 0.005). Treatment with 240 mg of diltiazem per day reduced angina frequency by 68 percent from the entry placebo period and 43 percent from the paired placebo period (p less than 0.01). There were similar reductions in nitroglycerin consumption. Adverse experiences that may have been related to the medication were noted in only 5 percent of patients. There were no alterations in blood pressure or heart rate. The PR interval increased 3 percent at the 240 mg dosage level. We conclude that diltiazem is an effective and safe agent for control of symptoms of Prinzmetal's angina.
J S Schroeder, and
R L Feldman, and
T D Giles, and
M J Friedman, and
A N DeMaria, and
E L Kinney, and
S M Mallon, and
B Pit, and
R Meyer, and
L L Basta, and
R C Curry, and
B M Groves, and
R N MacAlpin
April 1981,
The New England journal of medicine,
J S Schroeder, and
R L Feldman, and
T D Giles, and
M J Friedman, and
A N DeMaria, and
E L Kinney, and
S M Mallon, and
B Pit, and
R Meyer, and
L L Basta, and
R C Curry, and
B M Groves, and
R N MacAlpin
July 1985,
Journal of the American College of Cardiology,
J S Schroeder, and
R L Feldman, and
T D Giles, and
M J Friedman, and
A N DeMaria, and
E L Kinney, and
S M Mallon, and
B Pit, and
R Meyer, and
L L Basta, and
R C Curry, and
B M Groves, and
R N MacAlpin
January 1968,
Annales de cardiologie et d'angeiologie,
J S Schroeder, and
R L Feldman, and
T D Giles, and
M J Friedman, and
A N DeMaria, and
E L Kinney, and
S M Mallon, and
B Pit, and
R Meyer, and
L L Basta, and
R C Curry, and
B M Groves, and
R N MacAlpin
August 2006,
Kardiologia polska,
J S Schroeder, and
R L Feldman, and
T D Giles, and
M J Friedman, and
A N DeMaria, and
E L Kinney, and
S M Mallon, and
B Pit, and
R Meyer, and
L L Basta, and
R C Curry, and
B M Groves, and
R N MacAlpin
October 1978,
Vrachebnoe delo,
J S Schroeder, and
R L Feldman, and
T D Giles, and
M J Friedman, and
A N DeMaria, and
E L Kinney, and
S M Mallon, and
B Pit, and
R Meyer, and
L L Basta, and
R C Curry, and
B M Groves, and
R N MacAlpin
January 1980,
Kardiologia polska,
J S Schroeder, and
R L Feldman, and
T D Giles, and
M J Friedman, and
A N DeMaria, and
E L Kinney, and
S M Mallon, and
B Pit, and
R Meyer, and
L L Basta, and
R C Curry, and
B M Groves, and
R N MacAlpin
March 2000,
Circulation,
J S Schroeder, and
R L Feldman, and
T D Giles, and
M J Friedman, and
A N DeMaria, and
E L Kinney, and
S M Mallon, and
B Pit, and
R Meyer, and
L L Basta, and
R C Curry, and
B M Groves, and
R N MacAlpin
July 2004,
American journal of critical care : an official publication, American Association of Critical-Care Nurses,
J S Schroeder, and
R L Feldman, and
T D Giles, and
M J Friedman, and
A N DeMaria, and
E L Kinney, and
S M Mallon, and
B Pit, and
R Meyer, and
L L Basta, and
R C Curry, and
B M Groves, and
R N MacAlpin
July 1979,
Ugeskrift for laeger,
J S Schroeder, and
R L Feldman, and
T D Giles, and
M J Friedman, and
A N DeMaria, and
E L Kinney, and
S M Mallon, and
B Pit, and
R Meyer, and
L L Basta, and
R C Curry, and
B M Groves, and
R N MacAlpin
November 1979,
La Revue du praticien,
