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A case of malignant interstitial cell tumor of the testis is reported and the literature is reviewed. Malignant interstitial cell tumors occur exclusively in adults. Gynecomastia was noted in 12% of the cases. Elevated plasma levels or increased urinary excretion of estrogen, 17-ketosteroid, or testosterone were demonstrated in 64% of the patients. Vessel invasion, which occurred in 74% of the patients, appears to be the only reliable histologic feature for predicting malignant behavior. There is no proved sensitivity to radiation or chemotherapeutic regimens in patients with disseminated tumor. Once the diagnosis of malignancy is histologically established, inguinal and retroperitoneal lymph node dissections, even in the absence of clinical evidence of metastasis, may be beneficial in providing early staging of the tumor and, perhaps, in preventing subsequent lymphatic spread.
K T Chen, and
R W Spaulding, and
M S Flam, and
G M Brittin
January 1981,
Human pathology,
K T Chen, and
R W Spaulding, and
M S Flam, and
G M Brittin
September 1969,
Cancer,
K T Chen, and
R W Spaulding, and
M S Flam, and
G M Brittin
June 1963,
The Journal of urology,
K T Chen, and
R W Spaulding, and
M S Flam, and
G M Brittin
April 1960,
Chinese medical journal (Peking, China : 1932),
K T Chen, and
R W Spaulding, and
M S Flam, and
G M Brittin
September 1966,
The Journal of urology,
K T Chen, and
R W Spaulding, and
M S Flam, and
G M Brittin
May 1964,
American journal of surgery,
K T Chen, and
R W Spaulding, and
M S Flam, and
G M Brittin
June 1969,
Indian journal of cancer,
K T Chen, and
R W Spaulding, and
M S Flam, and
G M Brittin
March 1986,
The Journal of the Association of Physicians of India,
K T Chen, and
R W Spaulding, and
M S Flam, and
G M Brittin
November 1951,
The Journal of urology,
K T Chen, and
R W Spaulding, and
M S Flam, and
G M Brittin
March 1966,
Metabolism: clinical and experimental,
